64121-95-5

Basic information

• Product Name: schizandrin B
• CAS NO: 64121-95-5
• Molecular Weight: 0
• Mol File: 64121-95-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: schizandrin B(CAS DataBase Reference)
• NIST Chemistry Reference: schizandrin B(64121-95-5)
• EPA Substance Registry System: schizandrin B(64121-95-5)

Safety Data

• Hazardous Substances Data: 64121-95-5(Hazardous Substances Data)

Upstream product

• 5780-07-4 3-methoxy-4,5-methylenedioxybenzaldehyde 
• 76763-88-7 (R)-dihydro-4-(3,4,5-trimethoxybenzyl)furan-2(3H)-one 
• 161906-44-1 (R)-(E)-3-(3,4,5-trimethoxybenzyl)-2-(3,4-methylenedioxy-5-methoxy)butyrolactone 
• 82425-43-2 (+/-)-gomisin M₁ 
• 77-78-1 dimethyl sulfate 
• 148812-34-4 (3aRS,SR-Biar)-3a,4-dihydro-8,9,10,11-tetramethoxy-6,7-(methylenedioxy)dibenzo<4,5:6,7>cycloocta<1,2-c>furan-1(3H)-one 
• 82425-46-5 C₂₄H₂₈O₇ 
• 82425-45-4 (+)-gomisin M₂ 
• 82425-44-3 (-)-gomisin L₂ 
• 82425-43-2 (-)-gomisin L₁ 
• 62555-46-8 C₂₃H₂₆O₆ 
• 58546-54-6 gomisin A 

Relevant articles and documents

Identification of key structural characteristics of schisandra chinensis lignans involved in P-glycoprotein inhibition

The aim of the present study was to determine the structural requirements for dibenzocyclooctadiene lignans essential for P-glycoprotein inhibition. Altogether 15 structurally related lignans isolated from Schisandra chinensis or prepared by modification of their backbone were investigated, including three pairs of enantiomers. P-Glycoprotein inhibition was quantified using a doxorubicin accumulation assay in human promyelotic leukemia HL60/MDR cells overexpressing P-glycoprotein. A preliminary quantitative structure-activity relationship analysis revealed three main structural features involved in P-glycoprotein inhibition: a 1,2,3-trimethoxy moiety, a 6-acyloxy group, and the absence of a 7-hydroxy group. The most effective inhibitors, (-)-gomisin N (1) and (+)-deoxyschizandrin [(+)-2], were selected for further evaluation of their effects. Both these lignans restored the cytotoxic effect of doxorubicin in HL60/MDR cells and when combined with a subtoxic concentration of this compound increased the proportion of G2/M cells significantly, which is a usual response to treatment with this anticancer drug.

Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonists

We studied the structure-activity relationships of lignans from Schisandra chinensis and their derivatives as platelet activating factor (PAF) antagonists. Strong activity was shown in lignans without an ester group at C-6, a hydroxyl group at C-7 or a methylene dioxy moiety and with an R-biphenyl configuration. 6(7)-Dehydroschisandrol A, a derivative of schisandrol A, showed the highest activity (IC50, 2.1 x 10-6 M) in this study.

Kadsulignans L-N, three dibenzocyclooctadiene lignans from Kadsura coccinea

-