64123-72-4

Basic information

• Product Name: 3H-Pyrazol-3-one, 2,4-dihydro-5-(1-methylethyl)-2-phenyl-
• CAS NO: 64123-72-4
• Molecular Formula: C12H14N2O
• Molecular Weight: 202.256
• Mol File: 64123-72-4.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 3H-Pyrazol-3-one, 2,4-dihydro-5-(1-methylethyl)-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Pyrazol-3-one, 2,4-dihydro-5-(1-methylethyl)-2-phenyl-(64123-72-4)
• EPA Substance Registry System: 3H-Pyrazol-3-one, 2,4-dihydro-5-(1-methylethyl)-2-phenyl-(64123-72-4)

Safety Data

• Hazardous Substances Data: 64123-72-4(Hazardous Substances Data)

Upstream product

• 34036-16-3 5-methyl-3-oxo-hexanoic acid ethyl ester 
• 100-63-0 phenylhydrazine 
• 42558-54-3 Methyl 4-methyl-3-oxopentanoate 
• 59-88-1 phenylhydrazine hydrochloride 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 542-08-5 isopropyl acetoacetate 
• 1694-31-1 tert-butyl acetoacetate 
• 74-88-4 methyl iodide 

Downstream Products

• 909250-34-6 5-(4-chloro-phenoxy)-3-isopropyl-1-phenyl-1H-pyrazole-4-carbaldehyde 
• 861435-79-2 5-(4-chloro-phenoxy)-3-isopropyl-1-phenyl-1H-pyrazole-4-carbaldehyde oxime 
• 1198595-99-1 4,4-dibromo-3-isopropyl-1-phenyl-2-pyrazolin-5-one 
• 1208986-26-8 6-amino-4-(4-chlorophenyl)-3-isopropyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazol-5-yl cyanide 
• 1208986-27-9 6-amino-4-(2,4-dichlorophenyl)-3-isopropyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazol-5-yl cyanide 
• 1218782-30-9 4-hydroxy-3-isopropyl-1,5-diphenylpyrano[2,3-c]pyrazol-6-one 
• 1242100-46-4 1,4,5,6-tetrahydro-6-methyl-1,6-diphenyl-3-isopropyl-pyrano[2,3-c]pyrazole 
• 1311144-40-7 C₂₅H₂₆N₄O₂ 

Relevant articles and documents

Enantioselective Synthesis of Spiropyrazolone-Fused Cyclopenta[ c]chromen-4-ones Bearing Five Contiguous Stereocenters via (3+2) Cycloaddition

An enantioselective synthesis of spiropyrazolone-fused cyclopenta[c]chromen-4-ones is demonstrated via a (3+2) cycloaddition reaction. The reactions of 3-homoacylcoumarins and α,β-unsaturated pyrazolones in the presence of the cinchona-alkaloid derived hy

Catalytic Asymmetric Addition of Diorganozinc Reagents to Pyrazole-4,5-Diones and Indoline-2,3-Diones

The catalytic enantioselective diorganozinc additions to cyclic diketones including pyrazolin-4,5-diones and isatins have been developed. In the presence of morpholine-containing chiral amino alcohol ligand, the corresponding chiral cyclic tertiary alcohols were produced in good to excellent yields (up to 97 %) and enantioselectivities (up to 95 % ee). The notable feature of this protocol includes its mild reaction conditions, Lewis acid additives free and broad functional group tolerance.

Organophosphane-catalyzed direct β-acylation of 4-arylidene pyrazolones and 5-arylidene thiazolones with acyl chlorides

An efficient method for the direct β-acylation of arylidene pyrazolones and thiazolones with acyl chlorides in the presence of a base catalyzed by organophosphanes is reported. A variety of functionalized 4-arylidene pyrazolone and 5-arylidene thiazolone derivatives were prepared under metal-free and mild conditions via a tandem phospha-Michael addition/O-acylation/intramolecular cyclization/rearrangement sequence. Our mechanistic investigations revealed that the reaction is highly stereospecific to provide exclusively cis-isomers, and the methodology can also be scaled up with similar efficacy.