64139-40-8

Basic information

• Product Name: Propanoic acid, 3-(2,3-dimethoxyphenoxy)-
• Synonyms: 3-(2,3-Dimethoxy-phenoxy)-propionsaeure;3-(2,3-dimethoxy-phenoxy)-propionic acid
• CAS NO: 64139-40-8
• Molecular Formula: C11H14O5
• Molecular Weight: 226.229
• Mol File: 64139-40-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 101 °C
• Boiling Point: 329.9±27.0 °C(Predicted)
• Density: 1.196±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Propanoic acid, 3-(2,3-dimethoxyphenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 3-(2,3-dimethoxyphenoxy)-(64139-40-8)
• EPA Substance Registry System: Propanoic acid, 3-(2,3-dimethoxyphenoxy)-(64139-40-8)

Safety Data

• Hazardous Substances Data: 64139-40-8(Hazardous Substances Data)

Upstream product

• 107-94-8 chloropropionic acid 
• 5150-42-5 2,3-dimethoxyphenol 
• 57-57-8 β-Propiolactone 
• 590-92-1 3-Bromopropionic acid 

Downstream Products

• 89946-09-8 (E)-7,8-dimethoxy-3-(4'-hydroxybenzylidene)chroman-4-one 
• 1612925-51-5 (E)-2-(2-(6,7-dimethoxy-4H-chromeno[4,3-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid 
• 1612925-52-6 (Z)-2-(2-(6,7-dimethoxy-4H-chromeno[4,3-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid 
• 59887-97-7 7,8-dimethoxy-4-oxo-4H-1-benzopyran 

Relevant articles and documents

The Antiangiogenic Activity of Naturally Occurring and Synthetic Homoisoflavonoids from the Hyacinthaceae (sensu APGII)

Excessive blood vessel formation in the eye is implicated in wet age-related macular degeneration, proliferative diabetic retinopathy, neovascular glaucoma, and retinopathy of prematurity, which are major causes of blindness. Small molecule antiangiogenic

Anti-inflammatory activities of selected synthetic homoisoflavanones

Four homoisoflavanones of the 3-benzylidene-4-chromanone type, some of which were previously isolated from Caesalpinia pulcherrima, were synthesised to determine their anti-inflammatory activity and cytotoxicity. A range of four different homoisoflavanones (compounds 4a-4d) were synthesised from the corresponding substituted phenols.1H-and 13C-NMR data together with high-resolution mass spectroscopy data were employed to elucidate the structures. Anti-inflammatory activity was determined in mice with acute croton oil-induced auricular dermatitis. Invitro cytotoxicity was tested against a Chinese hamster ovarian cell line using the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazoliumbromide (MTT) assay. Compound 4a exhibited a tendency to inhibit oedema in a dose-dependent manner after 3 and 6 h of treatment. Compounds 4b-4d also inhibited oedema, although a clear dose-response relationship was not observed. Compounds 4a-4c were found to be less cytotoxic than compound 4d. Compound 4b was the least cytotoxic. Compounds 4a-4d exhibited anti-inflammatory activity and varying levels of cytotoxicity.