64182-58-7

Basic information

• Product Name: 1,3-Piperazinedicarboxylic acid, 4-(4-chloro-2-nitrophenyl)-, 1-(phenylmethyl) ester
• CAS NO: 64182-58-7
• Molecular Formula: C19H18ClN3O6
• Molecular Weight: 419.821
• Mol File: 64182-58-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-Piperazinedicarboxylic acid, 4-(4-chloro-2-nitrophenyl)-, 1-(phenylmethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Piperazinedicarboxylic acid, 4-(4-chloro-2-nitrophenyl)-, 1-(phenylmethyl) ester(64182-58-7)
• EPA Substance Registry System: 1,3-Piperazinedicarboxylic acid, 4-(4-chloro-2-nitrophenyl)-, 1-(phenylmethyl) ester(64182-58-7)

Safety Data

• Hazardous Substances Data: 64182-58-7(Hazardous Substances Data)

Upstream product

• 345-18-6 2-fluoro-5-chloronitrobenzene 
• 934630-06-5 4-(benzyloxy-carbonyl)-2-piperazinecarboxylic acid 

Downstream Products

• 64182-59-8 8-chloro-1,2,4,4a,5,6-hexahydro-pyrazino[1,2-a]quinoxaline-3-carboxylic acid benzyl ester 

Relevant articles and documents

Substituted pyrazinoquinoxaline derivatives as serotonin receptor agonist and antagonists ligands

The present invention is directed to novel compounds represented by structural Formulas (I) and (I-a): or a pharmaceutically acceptable salt thereof, wherein R1, R4a, R4b, R5, R6, R7, R8, R9, n, and X are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep and sexual disorders, migraine and other conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.

2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension

Compounds of the formula STR1 wherein R is hydrogen (lower)alkyl, phen(lower)alkyl, benzoyl(lower)alkyl, or p-halobenzoyl(lower)alkyl; R1 is hydrogen or (lower)alkyl; R2 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, trifluoromethyl, or amino in the 7-, 8-, or 9-position; R3 is hydrogen, or (lower)alkyl; and R4 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, or trifluoromethyl in the 7-, 8-, or 9-position; or the non-toxic acid addition salts thereof; exert a hypotensive effect in hypertensive animals.