64189-17-9Relevant articles and documents
Catalytic Asymmetric Allylic Substitution with Copper(I) Homoenolates Generated from Cyclopropanols
Shi, Chang-Yun,Yin, Liang,Zhang, Qi,Zhou, Si-Wei
supporting information, p. 26351 - 26356 (2021/11/09)
By using copper(I) homoenolates as nucleophiles, which are generated through the ring-opening of 1-substituted cyclopropane-1-ols, a catalytic asymmetric allylic substitution with allyl phosphates is achieved in high to excellent yields with high enantioselectivity. Both 1-substituted cyclopropane-1-ols and allylic phosphates enjoy broad substrate scopes. Remarkably, various functional groups, such as ether, ester, tosylate, imide, alcohol, nitro, and carbamate are well tolerated. Moreover, the present method is nicely extended to the asymmetric construction of quaternary carbon centers. Some control experiments argue against a radical-based reaction mechanism and a catalytic cycle based on a two-electron process is proposed. Finally, the synthetic utilities of the product are showcased by means of the transformations of the terminal olefin group and the ketone group.
Rhodium-Catalyzed Synthesis of α,β-Unsaturated Ketones through Sequential C-C Coupling and Redox Isomerization
Li, Hong-Shuang,Guo, Guili,Zhang, Rui-Ze,Li, Fei
supporting information, p. 5040 - 5043 (2018/08/24)
A novel Rh(I)-catalyzed sequential C-C coupling and redox isomerization between allylic alcohols and 1,3-dienes has been accomplished. This versatile protocol provides expeditious access to a broad range of polysubstituted α,β-unsaturated ketones with excellent atom economy and regioselectivity.
A plug intermediate body west that card 3 - (3-trifluoromethyl phenyl) propanol method for the synthesis of (by machine translation)
-
Paragraph 0017, (2016/11/17)
The invention discloses a plug intermediate body west that card 3 - (3-trifluoromethyl phenyl) propanol synthetic method, including: the trifluoromethyl benzaldehyde dissolved in a solvent, adding wittig agents and organic alkali, in 0-100 °C under a temperature condition after the reaction is complete, the post-processed to obtain 3 - (3-trifluoromethyl phenyl) 2-propen -1 alcohol; to 3 - (3-trifluoromethyl phenyl) 2-propen -1 catalyst Pd/C alcohol solution added in, and pressurized hydrogenation, in 0-60 °C under a temperature condition after the reaction is complete, the post-processed to obtain 3 - (3-trifluoromethyl phenyl) propanol. The preparation process of the present invention the easily obtained raw material used, the cost is low, and the reaction is controllable, the test operation is simplified, the operation is simple, is easy to deal with, high yield of the product, and can be operated continuously, is suitable for industrial production. (by machine translation)