6419-36-9

Basic information

• Product Name: 3-Pyridylacetic acid hydrochloride
• Synonyms: PYRIDIN-3-YLACETIC ACID HYDROCHLORIDE;PYRIDINE-3-ACETIC ACID HYDROCHLORIDE;2-(3-Pyridinyl)acetic acid;3-Pyridylactic Acid Hydrochloride;3-(acety acid)pyridine hydrochloride;Pyridine-3-acetic acid hydrochloride, 98+%;Risedronate Sodium intermediate;3-(acetic acid)pyridine hydrochloride
• CAS NO: 6419-36-9
• Molecular Formula: C₇H₈NO₂*Cl
• Molecular Weight: 173.6
• EINECS: 229-148-6
• Product Categories: Pyridine series;Pyridine;Acids and Derivatives;Heterocycles;Carboxylic Acids;Pyridines;Organic acids;Pyridines derivates;API intermediates;(intermediate of risedronate sodium);Building Blocks;Pyridinium Compounds;Carboxylic Acids;Aromatics, Heterocycles, Metabolites & Impurities
• Mol File: 6419-36-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 161-163 °C(lit.)
• Boiling Point: 301.6 °C at 760 mmHg
• Flash Point: 136.2 °C
• Appearance: White to light yellow or beige/Crystalline Powder, Crystals and/or Chunks
• Vapor Pressure: 0.000463mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• Stability: Hygroscopic
• Merck: 14,7971
• BRN: 3696630
• CAS DataBase Reference: 3-Pyridylacetic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridylacetic acid hydrochloride(6419-36-9)
• EPA Substance Registry System: 3-Pyridylacetic acid hydrochloride(6419-36-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10
• HazardClass: IRRITANT
• Hazardous Substances Data: 6419-36-9(Hazardous Substances Data)

Usage

Description

3-Pyridylacetic acid hydrochloride, also known as 3-PAA hydrochloride, is a chemical compound derived from the metabolite of nicotine. It is characterized by its unique structure, which consists of a pyridine ring attached to an acetic acid group, and is available as a hydrochloride salt. 3-Pyridylacetic acid hydrochloride exhibits antilipemic properties, making it a potential candidate for pharmaceutical applications.

Uses

Used in Pharmaceutical Applications:
3-Pyridylacetic acid hydrochloride is used as an antilipemic agent for the management of lipid metabolism disorders. Its ability to regulate lipid levels can contribute to the prevention and treatment of various cardiovascular diseases and other related health conditions.
Used in Analytical Chemistry:
3-Pyridylacetic acid hydrochloride serves as a secondary standard and is qualified as a Certified Reference Material. It is suitable for various analytical applications, including pharmaceutical release testing, method development for qualitative and quantitative analyses, and calibration requirements. This ensures the accuracy and reliability of analytical results in different industries.
Used in Food and Beverage Quality Control:
3-Pyridylacetic acid hydrochloride is utilized in food and beverage quality control testing to ensure the safety and compliance of products with established standards. Its use in this industry helps maintain the quality and integrity of food and beverage products, protecting consumers from potential health risks.

InChI:InChI=1/C7H7NO2/c9-7(10)4-6-2-1-3-8-5-6/h1-3,5H,4H2,(H,9,10)/p-1

Upstream product

• 15504-40-2 3-(pyridin-3-yl)pyruvic acid 
• 5423-64-3 (pyridin-3-yl)thioacetmorpholide 
• 350-03-8 methyl-3-pyridylketone 
• 501-81-5 pyridyl-3-yl-acetic acid 
• 61494-55-1 2-Chloro-pyridin-3-yl acetic acid 
• 110-91-8 morpholine 

Downstream Products

• 39998-25-9 methyl pyridine-3-acetate 
• 74104-94-2 pyridin-3-ylacetyl-Ala-Phe-Ile-Gly-Leu-Met-NH₂ 
• 6302-03-0 1-(pyridin-3-yl)-2-propanone 
• 6293-56-7 3-pyridinylethanol 
• 784987-54-8 1-benzyl-4-(pyridin-3-yl-acetyl)-piperazine 
• 899431-57-3 N-(2-chloro-4-fluoro-3-trifluoromethylphenyl)-2-pyridin-3-ylacetamide 
• 899431-55-1 N-(2,3-dichloro-4-fluorophenyl)-2-pyridin-3-ylacetamide 
• 899431-56-2 N-(2-chloro-3-trifluoromethylphenyl)-2-pyridin-3-ylacetamide 
• 899431-58-4 N-(2,3-dichlorophenyl)-2-pyridin-3-ylthioacetamide 
• 899431-60-8 N-(2-chloro-3-trifluoromethylphenyl)-2-pyridin-3-ylthioacetamide 
• 899431-61-9 N-(2-chloro-4-fluoro-3-trifluoromethylphenyl)-2-pyridin-3-ylthioacetamide 

Relevant articles and documents

Preparation method of 3-pyridylacetic acid hydrochloride

The invention discloses a preparation method of 3-pyridylacetic acid hydrochloride and belongs to the field of chemistry. A 3-pyridylacetic acid hydrochloride product is prepared from 3-methylpyridine chlorination side product 2-chloro-3-methylpyridine as a raw material through cyanidation, alkaline hydrolysis, hydrogenation reduction and salification. The 3-pyridylacetic acid hydrochloride product has purity of 98.5% or more.

Novel Process For Preparing Risedronic Acid

The present invention relates to a process for preparing risedronic acid comprising the step of combining a 3-pyridyl acetic acid or a salt thereof, phosphorous acid, and a halophosporous compound selected from PCl3, PClS, POCl3, PBr3, POBr3, and PBr5 in the presence of a diluent that is either a bicyclic aliphatic hydrocarbon or a substituted cyclic aliphatic hydrocarbon or a mixture thereof, in combination with a codiluent, that is orthophosphoric acid

Syntheses and UV/Vis-spectroscopic properties of hydrophilic 2-, 3-, and 4-pyridyl-substituted solvatochromic and halochromic pyridinium N-phenolate betaine dyes as new empirical solvent polarity indicators

Syntheses and negative solvatochromism of nine new hydrophilic 2-, 3-, and 4-pyridyl-substituted pyridinium N-phenolate betaine dyes 3-11 are described. These were produced in order to obtain zwitterionic dyes better soluble in water and other aqueous media (such as binary water/solvent mixtures, aqueous ionophore solutions) than the rather hydrophobic standard betaine dyes 1 and 2, which have been used to establish an empirical scale of solvent polarity, called the ET(30) scale. Betaine dye 8, in which three of the peripheral phenyl groups of 1 are replaced by two 3-pyridyl rings and one 4-pyridyl ring, proved to be particularly suitable for the determination of ET(30) values in aqueous media. Wiley-VCH Verlag GmbH, 2001.