642073-53-8

Basic information

• Product Name: N-Boc-Tyr(Bzl)-Asn-OMe
• Synonyms: N-Boc-Tyr(Bzl)-Asn-OMe
• CAS NO: 642073-53-8
• Molecular Weight: 499.564
• Mol File: 642073-53-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-Boc-Tyr(Bzl)-Asn-OMe(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-Tyr(Bzl)-Asn-OMe(642073-53-8)
• EPA Substance Registry System: N-Boc-Tyr(Bzl)-Asn-OMe(642073-53-8)

Safety Data

• Hazardous Substances Data: 642073-53-8(Hazardous Substances Data)

Upstream product

• 27601-29-2 t-butyloxycarbonyl-O-benzyl-L-tyrosine hydroxysuccinimide ester 
• 57461-34-4 L-asparagine methyl ester hydrochloride 

Downstream Products

• 700377-05-5 (S)-2-[(S)-3-(4-Benzyloxy-3-iodo-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-succinamic acid 
• 911675-30-4 N-Boc-Tyr(Bn)-Asn-OH 
• 642073-56-1 N-Boc-3-iodo-Tyr(Bzl)-Asn-OMe 

Relevant articles and documents

Synthesis of Macrocyclic Peptide Analogues of Proteasome Inhibitor TMC-95A

The synthesis of three constrained macrocyclic peptide analogues 1 of TMC-95A as potential proteasome inhibitors is described. The key step involves a Ni(O)-mediated macrocyclization of tripeptides 2 bearing halogenated aromatic side chains for the formation of the biaryl junction. In addition, an enantioselective preparation of L-7-bromotryptophan methyl ester 3 using a Corey-O'Donnell alkylation of the glycine benzophenone imine was achieved in good overall yield with very high ee (>85%) on a multigram scale.