64230-29-1Relevant articles and documents
Tuning iridium (I) PCcarbeneP frameworks for facile cooperative N2O reduction
Smith, Joel D.,Chih, Edwina,Piers, Warren E.,Spasyuk, Denis M.
, p. 281 - 290 (2018)
Two electron-rich PCP ligands were synthesized featuring –C(CH3)2? and –Si(CH3)2– functional groups linking the framework backbone. PCcarbeneP–Ir–Cl complexes were prepared via double C–H activation protocols and the donor strengths of the new ligands were evaluated using CO stretching frequencies of monocarbonyl cations prepared from the corresponding carbene chlorides. The new tethered systems were found to be superior donors with respect to PCcarbeneP pincer complexes previously reported in our group. These carbene chloride complexes reacted readily with nitrous oxide (N2O) to form “iridaepoxides” immune to unwanted Caryl–Canchor cleavage. Rates of oxygen atom transfer from N2O to a series of PCcarbeneP–Ir–Cl compounds were also measured using 31P{1H} NMR spectroscopy. Results suggested a direct positive correlation between ligand donicity and O-atom transfer rate for all ortho-phenylene derived systems. The sterically distinct 2,3-benzo[b]thiophene scaffold was found to be an outlier of this trend with a relatively high reactivity rate and νCO.
A curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in Alzheimer's disease
Park, Kwang-Su,Seo, Yujin,Kim, Mi Kyoung,Kim, Kyungdo,Kim, Yun Kyung,Choo, Hyunah,Chong, Youhoon
supporting information, p. 11194 - 11199 (2015/11/27)
In recent years, there has been growing interest in the near-infrared (NIR) fluorescence imaging of tau fibrils for the early diagnosis of Alzheimer's disease (AD). In order to develop a curcumin-based NIR fluorescent probe for tau fibrils, structural modification of the curcumin scaffold was attempted by combining the following rationales: the curcumin derivative should preserve its binding affinity to tau fibrils, and, upon binding to tau fibrils, the probe should show favorable fluorescence properties. To meet these requirements, we designed a novel curcumin scaffold with various aromatic substituents. Among the series, the curcumin derivative 1c with a (4-dimethylamino-2,6-dimethoxy)phenyl moiety showed a significant change in its fluorescence properties (22.9-fold increase in quantum yield; Kd, 0.77 μM; λem, 620 nm; Φ, 0.32) after binding to tau fibrils. In addition, fluorescence imaging of tau-green fluorescent protein-transfected SHSY-5Y cells with 1c confirmed that 1c detected tau fibrils in live cells.
