642442-49-7

Basic information

• Product Name: 4-(morpholine-4-carbonyl)benzoic acid ethyl ester
• Synonyms: 4-(morpholine-4-carbonyl)benzoic acid ethyl ester
• CAS NO: 642442-49-7
• Molecular Weight: 263.293
• Mol File: 642442-49-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 4-(morpholine-4-carbonyl)benzoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(morpholine-4-carbonyl)benzoic acid ethyl ester(642442-49-7)
• EPA Substance Registry System: 4-(morpholine-4-carbonyl)benzoic acid ethyl ester(642442-49-7)

Safety Data

• Hazardous Substances Data: 642442-49-7(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 67-66-3 chloroform 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 201230-82-2 carbon monoxide 
• 15226-74-1 dicobalt octacarbonyl 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 15159-40-7 4-morpholinocarbonyl chloride 
• 131379-15-2 (4-(ethoxycarbonyl)phenyl)zinc(ll) bromide 

Relevant articles and documents

Visible-Light-Mediated Efficient Metal-Free Catalyst for α-Oxygenation of Tertiary Amines to Amides

A metal-free system has been discovered for the efficient α-oxygenation of tertiary amines to the corresponding amides using oxygen as an oxidant. This visible-light-mediated oxygenation reaction exhibited excellent substrates scope under mild reaction conditions and generated water as the only byproduct. The synthetic utility of this approach has been demonstrated by applying onto drug molecules. At the end, detailed mechanistic reactions clearly showed the role of oxygen and the photocatalyst.

Photoinduced Aminocarbonylation of Aryl Iodides

Transition metal-catalyzed aminocarbonylation of aryl halides with CO and amines, pioneered by Heck and co-workers in the 1970s, is among the most commonly employed reactions to make aromatic amides. A catalyst-free aminocarbonylation of aryl iodides with CO and amines, which simply uses photoirradiation conditions by Xe-lamp, has now been developed. This methodology shows broad functional-group tolerance, including that of heteroaromatic amides. A hybrid radical/ionic chain mechanism, involving electron transfer from zwitterionic radical intermediates generated by nucleophilic attack of amines to aroyl radicals, is proposed.

Co2(CO)8 as a convenient in situ CO source for the direct synthesis of benzamides from aryl halides (Br/I) via aminocarbonylation

A fast, mild, and functional group tolerant method for the direct synthesis of benzamides from aryl halides (Br, I) via aminocarbonylation, using solid Co2(CO)8 as a convenient CO source, has been demonstrated. The developed method is applicable to a wide variety of 1 and cyclic and acyclic 2 amines. Nitro substituted (o, m and p) aryl halides have easily been converted to the corresponding benzamides, without the reduction of the nitro group, in high yields using this in situ carbonylation methodology under microwave irradiation.