64263-00-9

Basic information

• Product Name: 5,6-dimethyl-2-(pyridin-4-yl)-1H-benzo[d]imidazole
• Synonyms: 5,6-dimethyl-2-(pyridin-4-yl)-1H-benzo[d]imidazole
• CAS NO: 64263-00-9
• Molecular Formula: C₁₄H₁₃N₃
• Molecular Weight: 223.27312
• Mol File: 64263-00-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5,6-dimethyl-2-(pyridin-4-yl)-1H-benzo[d]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-dimethyl-2-(pyridin-4-yl)-1H-benzo[d]imidazole(64263-00-9)
• EPA Substance Registry System: 5,6-dimethyl-2-(pyridin-4-yl)-1H-benzo[d]imidazole(64263-00-9)

Safety Data

• Hazardous Substances Data: 64263-00-9(Hazardous Substances Data)

Upstream product

• 55-22-1 pyridine-4-carboxylic acid 
• 3171-45-7 4,5-dimethyl-1,2-phenylenediamine 
• 108-89-4 picoline 
• 6972-71-0 4,5-dimethyl-2-nitrobenzenamine 
• 872-85-5 pyridine-4-carbaldehyde 

Downstream Products

• 1609472-96-9 C₂₁H₁₅FN₄ 
• 1535187-22-4 C₂₁H₁₅FN₄ 

Relevant articles and documents

NOVEL SOLUBLE EPOXIDE HYDROLASE INHIBITORS AND METHOD OF USE THEREOF

Novel soluble epoxide hydrolase (sEH) inhibitors are provided, along with methods for their use. The soluble epoxide hydrolase inhibitors are useful in treating and/or preventing sEH-related related diseases, such as Alzheimer's disease and inflammation.

Substituted benzimidazoles as modulators of Ras signaling

Benzimidazole compounds that increase the rate of SOS-mediated nucleotide exchange on Ras by binding to a functionally relevant, chemically tractable pocket on the SOS protein, as part of the Ras:SOS:Ras complex.

Design, synthesis, binding and docking-based 3D-QSAR studies of 2-pyridylbenzimidazoles - A new family of high affinity CB1 cannabinoid ligands

A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 compounds displayed high affinities with Ki values in the nanomolar range. JM-39 (compound 39) was the most active of the series (KiCB1 = 0.53 nM), while compounds 31 and 44 exhibited similar affinities to WIN 55212-2. CoMFA analysis was performed based on the biological data obtained and resulted in a statistically significant CoMFA model with high predictive value (q2 = 0.710, r2 = 0.998, r2pred = 0.823).