64287-19-0

Basic information

• Product Name: 4-FLUORO-3-METHOXYACETOPHENONE
• Synonyms: 4'-FLUORO-3'-METHOXYACETOPHENONE;4-FLUORO-3-METHOXYACETOPHENONE;3-methoxy-4-fluoroacetophenone;1-(4-fluoro-3-methoxyphenyl)ethanone;4'-Fluoro-3'-methoxyacetophenone 99+%;1-(4-Fluoro-3-methoxyphenyl)ethan-1-one;4'-fluoro-3'-methoxyacetophenone;1-(4-Fluoro-3-methoxyphenyl)ethan-1-one, 5-Acetyl-2-fluoroanisole
• CAS NO: 64287-19-0
• Molecular Formula: C₉H₉FO₂
• Molecular Weight: 168.16
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);Adehydes, Acetals & Ketones;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Fluorine series
• Mol File: 64287-19-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 52 °C
• Boiling Point: 246 °C at 760 mmHg
• Flash Point: 99.6 °C
• Appearance: /
• Density: 1.127g/cm³
• Vapor Pressure: 0.0159mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 4381319
• CAS DataBase Reference: 4-FLUORO-3-METHOXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-3-METHOXYACETOPHENONE(64287-19-0)
• EPA Substance Registry System: 4-FLUORO-3-METHOXYACETOPHENONE(64287-19-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36
• Hazardous Substances Data: 64287-19-0(Hazardous Substances Data)

Usage

Uses

4''-Fluoro-3''-methoxyacetophenone

InChI:InChI=1/C8H7F2NO/c9-5-1-2-6(7(10)3-5)8(12)4-11/h1-3H,4,11H2

Upstream product

• 949159-95-9 1-(4-fluoro-3-hydroxyphenyl)ethan-1-one 
• 74-88-4 methyl iodide 
• 82846-18-2 4?fluoro-3-methoxybenzoic acid 
• 1262882-70-1 4-fluoro-N,3-dimethoxy-N-methylbenzamide 
• 75-16-1 methylmagnesium bromide 
• 128495-46-5 4-fluoro-3-methoxybenzaldehyde 
• 870849-56-2 1-(4-fluoro-3-methoxyphenyl)ethan-1-ol 

Downstream Products

• 87054-30-6 2,3-Bis-(4-fluoro-3-methoxy-phenyl)-butane-2,3-diol 
• 443914-95-2 2-bromo-1-(4-fluoro-3-methoxy-phenyl)ethanone 
• 949159-96-0 1-(4-fluoro-5-methoxy-2-nitrophenyl)ethanone 
• 949159-95-9 1-(4-fluoro-3-hydroxyphenyl)ethan-1-one 
• 1072710-29-2 4'-fluoro-3'-methoxyacetophenone-O-[(benzo[c][1,2,5]oxadiazol-5-yl)methyl]oxime 
• 552299-41-9 1-(4-fluoro-3-methoxyphenyl)-3,3-bis(methylsulfanyl)-2-propen-1-one 
• 949159-97-1 1-(2-amino-4-fluoro-5-methoxyphenyl)ethan-1-one 
• 1378294-19-9 7-(benzyloxy)-4-bromo-6-methoxycinnoline 
• 1378294-21-3 7-(benzyloxy)-4-(6-fluoro-5-methylpyridin-3-yl)-6-methoxycinnoline 
• 333753-64-3 1-(4-fluoro-3-methoxyphenyl)ethanamine 

Relevant articles and documents

Nucleophilic aromatic substitution of unactivated fluoroarenes enabled by organic photoredox catalysis

Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented. Herein, we present a method for the nucleophilic defluorination of unactivated fluoroarenes enabled by cation radical-accelerated nucleophilic aromatic substitution. The use of organic photoredox catalysis renders this method operationally simple under mild conditions and is amenable to various nucleophile classes, including azoles, amines, and carboxylic acids. Select fluorinated heterocycles can be functionalized using this method. In addition, the late-stage functionalization of pharmaceuticals is also presented. Computational studies demonstrate that the site selectivity of the reaction is dictated by arene electronics.

COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF

The present disclosure relates to a compound of formula I, a pharmaceutical composition thereof and the use thereof as an anti-tumor drug.