6429-10-3

Basic information

• Product Name: 4-(2-CHLORO-ETHYL)-1H-IMIDAZOLE HCL
• Synonyms: 4-(2-CHLORO-ETHYL)-1H-IMIDAZOLE HCL;2-(2-Chloroethyl)-1H-imidazole;4-(2-Chloroethyl)-1H-imidazole hydrochloride;4-(2-Chloroethyl)imidazole hydrochloride;5-(2-Chloroethyl)-1H-imidazole hydrochloride;1H-IMidazole,5-(2-chloroethyl)-, hydrochloride (1:1);5-(2-Chloroethyl)
• CAS NO: 6429-10-3
• Molecular Formula: C₅H₇ClN₂*ClH
• Molecular Weight: 167.03642
• Mol File: 6429-10-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 347 °C at 760 mmHg
• Flash Point: 163.7 °C
• Appearance: /
• Vapor Pressure: 3.92E-05mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-(2-CHLORO-ETHYL)-1H-IMIDAZOLE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-CHLORO-ETHYL)-1H-IMIDAZOLE HCL(6429-10-3)
• EPA Substance Registry System: 4-(2-CHLORO-ETHYL)-1H-IMIDAZOLE HCL(6429-10-3)

Safety Data

• Hazardous Substances Data: 6429-10-3(Hazardous Substances Data)

Usage

General Description

4-(2-Chloro-ethyl)-1H-imidazole HCl, also known as Cloridine hydrochloride, is a chemical compound belonging to the imidazole group. Imidazoles are heterocyclic aromatic organic compounds having a five-membered ring of two nitrogen atoms at non-adjacent positions. It is commonly used as a reagent in chemistry for the synthesis of other organic compounds. This specific compound with a chlorine atom and an ethyl group attached to the imidazole ring has applications in the pharmaceutical industry due to its potential biological activity. Like other imidazoles, it is a weak base, and in the presence of hydrochloric acid, it forms a salt — hence, the specification 'HCl'.

InChI:InChI=1/C5H7ClN2.ClH/c6-2-1-5-3-7-4-8-5;/h3-4H,1-2H2,(H,7,8);1H

Upstream product

• 56-92-8 histamine dichloride 

Downstream Products

• 7728-79-2 4-(2-[2]naphthyloxy-ethyl)-1(3)H-imidazole 
• 673-50-7 N-methyl-2-(1H-imidazol-4-yl)ethanamine 
• 108565-50-0 bis-[2-(1⁽³⁾H-imidazol-4-yl)-ethyl]-methyl-amine 
• 131727-43-0 N-(phenyl)-N-[1-(2-(1H-imidazol-4-yl)ethyl)-4-methoxymethyl-4-piperidinyl]propanamide 
• 131727-41-8 N-(phenyl)-N-[1-(2-(1H-imidazol-4-yl)ethyl)-4-methoxycarbonyl-4-piperidinyl]propanamide 
• 185849-99-4 4-(2-Chloro-ethyl)-1-(toluene-4-sulfonyl)-1H-imidazole 

Relevant articles and documents

Rigid Oxazole Acinetobactin Analog Blocks Siderophore Cycling in Acinetobacter baumannii

The emergence of multidrug resistant (MDR) Gram-negative bacterial pathogens has raised global concern. Nontraditional therapeutic strategies, including antivirulence approaches, are gaining traction as a means of applying less selective pressure for resistance in vivo. Here, we show that rigidifying the structure of the siderophore preacinetobactin from MDR Acinetobacter baumannii via oxidation of the phenolate-oxazoline moiety to a phenolate-oxazole results in a potent inhibitor of siderophore transport and imparts a bacteriostatic effect at low micromolar concentrations under infection-like conditions.

Triggering DNAzymes with light: A photoactive C8 thioether-linked adenosine

Herein we report evidence for a light-inducible DNAzyme. In so doing, we also disclose the synthesis and photochemical properties of a novel nucleoside: 8-(2-(4-imidazolyl)ethyl-1-thio)-2′-deoxyriboadenosine (d1). The light sensitivity of (d1) was evaluated via an examination of the photoinduced reactivation of DNAzyme 8-17E from an inactive form that contained a single nucleotide (d1) modification. Restoration of DNAzyme activity results from a photoinduced reversion of (d1) to unmodified deoxyadenosine. Deuterium studies indicate that water is the source of hydrogen in the C8-H product and not the alkylthio group, suggesting that reversion of (1) to adenosine is not a consequence of simple homolysis of the C8-S bond but of an unprecedented photochemical conversion. This adenosine, which affords significant control of catalytic reactivation of a DNAzyme, may find general use in photodecaging other biological systems. Copyright