64325-07-1

Basic information

• Product Name: L-Phenylalanine, N-acetyl-3-hydroxy-
• CAS NO: 64325-07-1
• Molecular Formula: C11H13NO4
• Molecular Weight: 223.229
• Mol File: 64325-07-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, N-acetyl-3-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, N-acetyl-3-hydroxy-(64325-07-1)
• EPA Substance Registry System: L-Phenylalanine, N-acetyl-3-hydroxy-(64325-07-1)

Safety Data

• Hazardous Substances Data: 64325-07-1(Hazardous Substances Data)

Upstream product

• 60521-82-6 2-acetylamino-3-(3-hydroxyphenyl)propionic acid methyl ester 
• 587-33-7 m-tyrosine 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 565458-30-2 2-(3-hydroxybenzyl)malonic acid dimethyl ester 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 587-33-7 m-tyrosine 

Relevant articles and documents

MACROCYCLIC COMPOUNDS AS PROTEASOME INHIBITORS

The compounds of the present invention are represented by the following compounds having Formula I and Formula (I'): where the substituents R1, R2, R2', R3, R4, R5, R', R", X, Y, and Z are as defined herein and where the substituents R1, R2, R3, R4, R5, R', R", X, Y, and Z are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.

Optimized synthesis of L-m-tyrosine suitable for chemical scale-up

This paper demonstrates how L-m-tyrosine 1 can be synthesized on larger-scale via enzyme-catalyzed kinetic resolution of N-acyl m-tyrosine methyl ester 4. N-Acyl m-tyrosme methyl ester 4 was prepared by a modification of Erlenmeyer's azalactone synthesis followed by hydrogenation of the resultant dehydroamino acid 12. The optimized four-step synthesis utilizes cheap and readily available starting materials and circumvents difficult purification protocols.