64365-27-1

Basic information

• Product Name: AC-ARG-NH2 SALT
• Synonyms: AC-ARG-NH2 SALT;N-ALPHA-ACETYL-L-ARGININE AMIDE SALT;Ac-Arg-NH2
• CAS NO: 64365-27-1
• Molecular Formula: C8H17N5O2
• Molecular Weight: 215.25
• Mol File: 64365-27-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.38g/cm³
• Refractive Index: 1.597
• PKA: 14.93±0.46(Predicted)
• CAS DataBase Reference: AC-ARG-NH2 SALT(CAS DataBase Reference)
• NIST Chemistry Reference: AC-ARG-NH2 SALT(64365-27-1)
• EPA Substance Registry System: AC-ARG-NH2 SALT(64365-27-1)

Safety Data

• Hazardous Substances Data: 64365-27-1(Hazardous Substances Data)

Usage

General Description

AC-ARG-NH2 SALT is a chemical compound known as acetyl-arginine amide hydrochloride. It is a salt form of acetyl-arginine amide, an amino acid derivative. The compound is commonly used in research and laboratory settings for its potential biological activities and as a building block for peptide synthesis. AC-ARG-NH2 SALT may have various biochemical and pharmacological effects, and its properties make it useful for studying peptide structures and functions. It has also been investigated for its potential therapeutic applications, particularly in the field of neuropharmacology. Overall, AC-ARG-NH2 SALT is a versatile chemical that has various research and potential therapeutic uses due to its structural and functional properties.

InChI:InChI=1/C8H17N5O2/c1-5(14)13-7(15)6(9)3-2-4-12-8(10)11/h6H,2-4,9H2,1H3,(H4,10,11,12)(H,13,14,15)

Relevant articles and documents

Conjugation of a new series of dithiocarbazate schiff base copper(II) complexes with vectors selected to enhance antibacterial activity

A new series of six Schiff bases derived from S-methyldithiocarbazate (SMDTC) and S-benzyldithiocarbazate (SBDTC) with methyl levulinate (SMML, SBML), levulinic acid (SMLA, SBLA), and 4-carboxybenzaldehyde (SM4CB, SB4CB) were reacted with copper(II), producing complexes of general formula ML2 (M = Cu(II), L = ligand). All compounds were characterized using established physicochemical and spectroscopic methods. Crystal structures were determined for three Schiff bases (SMML, SBML, SBLA) and two Cu(II) complexes (Cu(SMML)2 and Cu(SMLA)2). In order to provide more insight into the behavior of the complexes in solution, electron paramagnetic resonance (EPR) and electrochemical experiments were performed. The parent ligands and their respective copper(II) complexes exhibited moderate antibacterial activity against both Gram-negative and Gram-positive bacteria. The most active ligand (SB4CB) and its analogous S-methyl derivative (SM4CB) were conjugated with various vector moieties: polyarginines (R1, R4, R9, and RW9), oligoethylene glycol (OEG), and an efflux pump blocker, phenylalanine-arginine-β-naphthylamide (PAβN). Nonaarginine (R9) derivatives showed the most encouraging synergistic e ffects upon conjugation and complexation with copper ion including enhanced water solubility, bacteria cell membrane permeability, and bioactivity. These Cu(II)-R9 derivatives display remarkable antibacterial activity against a wide spectrum of bacteria and, in particular, are highly efficacious against Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 0.5-1 μM. This pioneer study clearly indicates that the conjugation of cell-penetrating peptides (CPPs) to dithiocarbazate compounds greatly enhances their therapeutic potential.