64398-92-1

Basic information

• Product Name: 4-chloro-N-(oxiran-2-ylmethyl)aniline
• CAS NO: 64398-92-1
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.6348
• Mol File: 64398-92-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 327.8°C at 760 mmHg
• Flash Point: 152°C
• Density: 1.3g/cm³
• Vapor Pressure: 0.000198mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: 4-chloro-N-(oxiran-2-ylmethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-(oxiran-2-ylmethyl)aniline(64398-92-1)
• EPA Substance Registry System: 4-chloro-N-(oxiran-2-ylmethyl)aniline(64398-92-1)

Safety Data

• Hazardous Substances Data: 64398-92-1(Hazardous Substances Data)

Upstream product

• 20265-96-7 p-chloroaniline hydrochloride 
• 106-89-8 epichlorohydrin 
• 60378-03-2 4-chloro-N-(3-chloro-2-hydroxypropyl)aniline 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 1198800-67-7 1-(4-benzhydrylpiperazin-1-yl)-3-(4-chlorophenylamino)propan-2-ol 

Relevant articles and documents

Stereocontrolled, Divergent, Al(lll)-Catalyzed Coupling of Chiral N-Aryl Epoxy Amines and CO2

A divergent coupling reaction was achieved between N-aryl epoxy amines and CO2. By using two different cocatalysts, tetrabutylammonium iodide (TBAI) or 4-dimethylaminopyridine (DMAP) together with an Al(III) Lewis acid, cyclic carbonates or oxazolidinones were selectively produced through two distinct reaction pathways, respectively. The proposed reaction mechanism was supported by the stereochemical determination of the products. A gram-scale production of Linezolid was successfully achieved.

Highly regioselective and efficient synthesis of aminoepoxides by ring closure of aminohalohydrins mediated by KF-Celite

The regioselective synthesis of several aminoepoxides has been achieved without observing any trace of azetidinols, which are usually reported as the exclusive reaction products when aminohalohydrins are treated with bases. The use of the mild supported base KF-Celite in refluxing acetonitrile is crucial for modulating the excellent regioselectivity observed. Georg Thieme Verlag Stuttgart . New York.