64434-29-3

Basic information

• Product Name: 1(2H)-Isoquinolinone, 6,7-dimethoxy-2-(phenylmethyl)-
• CAS NO: 64434-29-3
• Molecular Formula: C18H17NO3
• Molecular Weight: 295.338
• Mol File: 64434-29-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1(2H)-Isoquinolinone, 6,7-dimethoxy-2-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Isoquinolinone, 6,7-dimethoxy-2-(phenylmethyl)-(64434-29-3)
• EPA Substance Registry System: 1(2H)-Isoquinolinone, 6,7-dimethoxy-2-(phenylmethyl)-(64434-29-3)

Safety Data

• Hazardous Substances Data: 64434-29-3(Hazardous Substances Data)

Upstream product

• 15248-39-2 6,7-dimethoxyisoquinoline 
• 100-44-7 benzyl chloride 
• 16101-63-6 6,7-dimethoxyisoquinoline-1(2H)-one 

Relevant articles and documents

Discovery of novel 2-benzylisoquinolin-1(2H)-ones as potent vasodilative agents

2-Benzylisoquinolin-1(2H)-ones has been proposed as vasodilative agents on the basis of scaffold hopping. In the present study, a series of 2-benzylisoquinolin-1(2H)-ones were synthesized. Their vasodilative effects were evaluated by wire myograph on isolated rat mesenteric arterial ring induced contraction with 60 mM KCl. The structure-activity relationships of target compounds were discussed. Among these compounds, C7 and C8 displayed potent vasodilative effects and significantly inhibited the contraction of rat mesenteric arterial rings induced by phenylephrine. The antihypertensive effects of compounds C7 and C8 on SHR were further evaluated. The results indicated that oral administrational C7 and C8 can significantly reduce both diastolic and systolic blood pressure in a dose-dependent manner. Moreover, C7 maintained the effects for 4 h at a dosage of 4.0 mg/kg. These findings suggest that the title compounds can serve as novel vasodilative agents and promising antihypertensive agents.

Ruthenium-Mediated Dual Catalytic Reactions of Isoquinoline via C?H Activation and Dearomatization for Isoquinolone

We have unraveled the ruthenium-promoted prototype reaction based on C(sp2)?C(sp3) bond formation through the reigoselective C?H activation of isoquinoline and pyridine derivatives with various alkyl halides, leading to 1-substituted isoquinoline products in good yield. This C?H catalytic reaction did not rely on chelation assistance of the directing group of the substrates. The dimer [RuCl2(p-cymene)]2in combination with an N-heterocyclic carbene ligand, adamantanecarboxylic acid and K2CO3base in N-methyl-2-pyrrolidone solution at 150 °C are the best conditions. Simultaneously, we are also able to chemically tune the reaction mode to dearomatization by adding water, leading to isoquinolone products. This reaction methodology is not suitable for other nitrogen-containing heteroarenes such as pyridazines and pyrimidines. (Figure presented.).