64456-61-7Relevant articles and documents
Catalytic α-Arylation of Imines Leading to N-Unprotected Indoles and Azaindoles
Marelli, Enrico,Corpet, Martin,Minenkov, Yury,Neyyappadath, Rifahath M.,Bismuto, Alessandro,Buccolini, Giulia,Curcio, Massimiliano,Cavallo, Luigi,Nolan, Steven P.
, p. 2930 - 2938 (2016)
A palladium N-heterocyclic carbene catalyzed methodology for the synthesis of substituted, N-unprotected indoles and azaindoles is reported. The protocol permits access to various, highly substituted members of these classes of compounds. Although two possible reaction pathways (deprotonative and Heck-like) can be proposed, control experiments, supported by computational studies, point toward a deprotonative mechanism being operative.