64460-41-9

Basic information

• Product Name: Pyridin-4-ylmethanamine hydrochloride
• Synonyms: Pyridin-4-ylmethanamine Hcl;Pyridin-4-ylmethanamine hydrochloride;Nsc194303;4-Pyridinemethanamine,hydrochloride;4-(AMINOMETHYL)PYRIDINEhydrochloride
• CAS NO: 64460-41-9
• Molecular Formula: C₆H₈N₂*2ClH
• Molecular Weight: 144.6
• Mol File: 64460-41-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 207-208 °C
• Boiling Point: 230 °C at 760 mmHg
• Flash Point: 108.3 °C
• Appearance: /
• Vapor Pressure: 0.0674mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: Pyridin-4-ylmethanamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridin-4-ylmethanamine hydrochloride(64460-41-9)
• EPA Substance Registry System: Pyridin-4-ylmethanamine hydrochloride(64460-41-9)

Safety Data

• Hazardous Substances Data: 64460-41-9(Hazardous Substances Data)

Usage

General Description

Pyridin-4-ylmethanamine hydrochloride, also known as 4-picolylamine hydrochloride, is a chemical compound with the molecular formula C6H9N2?HCl. It is a hydrochloride salt form of 4-picolylamine, a derivative of pyridine. This chemical is used in various industrial and pharmaceutical applications, including as a building block for the synthesis of pharmaceutical compounds and as a ligand in coordination chemistry. It is also used as a reagent in organic synthesis and as a catalyst in chemical reactions. Additionally, it has potential applications in the field of crop protection and agrochemicals. Pyridin-4-ylmethanamine hydrochloride is known for its strong odor and should be handled with caution due to its potential irritant and toxic properties.

InChI:InChI=1/C6H8N2.ClH/c7-5-6-1-3-8-4-2-6;/h1-4H,5,7H2;1H

Upstream product

• 85127-48-6 4-(1-acetyl-4(1H)-pyridylidene)-2-methyl-2-oxazolin-5-one 
• 110-86-1 pyridine 
• 872-85-5 pyridine-4-carbaldehyde 
• 1822-51-1 4-picolylchloride hydrochloride 
• 1453-82-3 isonicotinamide 

Downstream Products

• 1257425-10-7 4-phenyl-3-(pyridine-4-ylmethyl)thiazol-2(3H)imine 
• 1257425-11-8 3-(pyridine-4-ylmethyl)-4-p-tolylthiazol-2(3H)imine 
• 1257425-13-0 4-(4-chlorophenyl)-3-(pyridine-4-ylmethyl)thiazol-2(3H)imine 
• 1257425-12-9 4-(4-methoxyphenyl)-3-(pyridine-4-ylmethyl)thiazol-2(3H)imine 

Relevant articles and documents

Fabrication of ω-Transaminase@Metal-Organic Framework Biocomposites for Efficiently Synthesizing Benzylamines and Pyridylmethylamines

In this study, ten ω-transaminases (ω-TAs) have been investigated to efficiently catalyze the synthesis of twenty-four functionalized benzylamines and pyridylmethylamines. We optimized the reactions, screened suitable amino donors and compared ω-transaminases activities for all aromatic aldehyde substrates. Under the optimized conditions, eighteen aromatic amines have been obtained with 60.4%–96.6% conversions and isolated only via simple extraction and recrystallization with 18.5%–81% yields on a preparative scale. Furthermore, we first immobilized the Bm-STA onto the MOFs via the physical adsorption to overcome the limitation of free enzyme and improve their industrial applications. The obtained Bm-STA/UiO-66-NH2 composites exhibited not only high enzymes loading (80.4 mg g?1) and enzyme activity recovery (95.8%), but also the better reusability, storage stability, pH stability and the tolerance to acetone and DMF.

Microwave-assisted synthesis of primary amine HX salts from halides and 7 M ammonia in methanol

The atom economical synthesis of hydrogen halide salts of primary amines, directly from the corresponding halides, avoids the production of significant amounts of secondary amine side products, and requires only evaporation of the solvent to access the products in yields generally greater than 90%. The procedure uses microwave irradiation in 7 M ammonia in methanol (Aldrich) at 130°C from 0.5 to 2.5h and works on a variety of alkyl halides, as well as mesylates and tosylates. Benzylamines are obtained from benzyl halides without significant amounts of the secondary amine side products that result without microwave heating. Direct isolation of even highly volatile primary amines as their hydrogen halide salts makes the method ideal for use in parallel synthesis.