64483-69-8

Basic information

• Product Name: 5-Acetyloxindole
• Synonyms: 5-ACETYLOXINDOLE;5-acetylindolin-2-one;5-acetyl-2-indolinone;1H-indol-5-yl acetate;5-Acetyl-1,3-dihydro-indol-2-one;2H-Indol-2-one,5-acetyl-1,3-dihydro-
• CAS NO: 64483-69-8
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• Product Categories: Indoline & Oxindole
• Mol File: 64483-69-8.mol
• Article Data: 27

Chemical Properties

• Melting Point: 225-227 °C
• Boiling Point: 418.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.228±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.46±0.20(Predicted)
• CAS DataBase Reference: 5-Acetyloxindole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Acetyloxindole(64483-69-8)
• EPA Substance Registry System: 5-Acetyloxindole(64483-69-8)

Safety Data

• Hazardous Substances Data: 64483-69-8(Hazardous Substances Data)

Usage

General Description

5-Acetyloxindole is a chemical compound with the molecular formula C10H9NO2. It is an indole derivative that is commonly used in organic synthesis and pharmaceutical research. 5-Acetyloxindole has been investigated for its potential pharmacological activities, including anti-inflammatory, anti-cancer, and anti-viral properties. It has also been studied for its role in the synthesis of various natural products and pharmaceutical compounds. The compound is typically produced through chemical reactions involving indole and acetyl chloride, and it is known for its characteristic aromatic and reactive properties. Overall, 5-Acetyloxindole is a versatile compound with various potential applications in the fields of chemistry and medicine.

Upstream product

• 59-48-3 2-oxoindole 
• 75-36-5 acetyl chloride 

Downstream Products

• 107316-17-6 1-(N-benzoylcarbamoyl)-5-acetyloxindole 
• 864688-87-9 (Z)-1,1'-(3-(ethoxy(phenyl)methylene)-2-oxoindoline-1,5-diyl)bis(ethan-1-one) 
• 220991-32-2 5-ethyl-2-(2',3',5',6'-tetrafluoroanilino)-phenylacetic acid 

Relevant articles and documents

Yb(OTf)3catalyzed [1,3]-rearrangement of 3-alkenyl oxindoles

A Yb(OTf)3catalyzed [1,3]-rearrangement of 3-alkenyl oxindoles was achieved, affording a variety of multifunctional 3-ylideneoxindoles with good yields andZ/Eselectivities (64%-89% yield, 78?:?22->99?:?1Z/E). Importantly, an operationally simple, one-pot sequential catalytic synthesis of 3-ylideneoxindoles was also developed. Additionally, a cross [1,3]-rearrangement experiment and nonracemic transformation were also carried out, which indicated a concerted rearrangement mechanism of this methodology.

Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth

Despite recent advances in molecularly directed therapy, triple negative breast cancer (TNBC) remains one of the most aggressive forms of breast cancer, still without a suitable target for specific inhibitors. Maternal embryonic leucine zipper kinase (MELK) is highly expressed in TNBC, where level of overexpression correlates with poor prognosis and an aggressive disease course. Herein, we describe the discovery through targeted kinase inhibitor library screening, and structure-guided design of a series of ATP-competitive indolinone derivatives with subnanomolar inhibition constants towards MELK. The most potent compound, 17, inhibits the expression of the anti-apoptotic protein Mcl-1 and proliferation of TNBC cells exhibiting selectivity for cells expressing high levels of MELK. These studies suggest that further elaboration of 17 will furnish MELK-selective inhibitors with potential for development in preclinical models of TNBC and other cancers.

Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors

The present invention relates to inhibitors of protein kinases of formula I: which can be used in the treatment of various diseases, notably cancer, inflammation or disorders of the central nervous system. It also relates to pharmaceutical compositions containing the compounds according to the invention and their use in therapy.