644968-01-4

Basic information

• Product Name: 4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
• Synonyms: 4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
• CAS NO: 644968-01-4
• Molecular Weight: 339.407
• Mol File: 644968-01-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester(644968-01-4)
• EPA Substance Registry System: 4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester(644968-01-4)

Safety Data

• Hazardous Substances Data: 644968-01-4(Hazardous Substances Data)

Upstream product

• 147804-30-6 1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester 
• 188132-02-7 (5-fluoro-2-methoxyphenyl)magnesium bromide 
• 452-08-4 2-bromo-4-fluoro-1-methoxybenzene 

Downstream Products

• 644968-05-8 5-fluorospiro[1-benzofuran-2,4'-piperidine] hydrochloride 
• 1427190-09-7 C₂₂H₂₅FN₂O₆ 
• 1427190-06-4 C₂₄H₃₀FN₃O₄ 
• 1427190-12-2 C₃₄H₄₆FN₃O₈ 

Relevant articles and documents

Spirocyclic compounds, potent CCR1 antagonists

Conformationally constrained spirocycles (17-23) and (31-36) were synthesised. In vitro data revealed that these compounds are CCR1 antagonists with sub-nanomolar potency. In a functional assay 22, 23 and 36 inhibited CCR1 mediated chemotaxis with an ICs

NOVEL TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES

The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, Z, R3, R4, R5, R6, R7, R8, t and R9 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.