644985-24-0Relevant articles and documents
(AZA)INDAZOLYL-ARYL SULFONAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS
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Paragraph 0327; 0405, (2020/10/21)
The invention provides (aza)indazolyl-aryl sulfonamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as cancer, and in inhibiting GCN2 activity.
Compound
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Paragraph 0041; 0042, (2018/08/28)
PROBLEM TO BE SOLVED: To provide a difluorobenzyl halide derivative useful as a production intermediate for chemicals etc., such as pharmaceuticals, agrochemicals and liquid crystal materials, and a method for efficiently producing the difluorobenzyl halide derivative.SOLUTION: There is provided a compound expressed by general formula (I) (in the formula, Ris a hydrogen atom, chlorine atom, bromine atom, iodine atom or 1-15C alkyl; A, Aand Aare each independently trans-1,4-cyclohexylene wherein one or more ring-constituting methylene groups may be substituted with an oxygen atom or sulfur atom, or 1,4-phenylene wherein one or more hydrogen atoms on a ring may be substituted with a fluorine atom; Z, Zand Zare each independently a single bond, -CHCH-, -(CH)-, -CHO- or -OCH-; l, m and n are each independently 0 or 1; and Xis a chlorine atom, bromine atom or iodine atom).
HETEROCYCLIC ANTIVIRAL COMPOUNDS
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Page/Page column 26, (2009/07/17)
Compounds of formula I, wherein R1, R2, R3, X1, X2 and Ar, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.