645-35-2

Basic information

• Product Name: L-Histidine hydrochloride
• Synonyms: monohydrochloride,l-histidin;HISTIDINE-L HCL;L-HISTIDINE HCL;L-(+)-HISTIDINE MONOHYDROCHLORIDE;L-HISTIDINE MONOHYDROCHLORIDE;L-Histidine hydrochloride;L-Histidine·hydrochloric acid;(-)-Histidine monohydrochloride
• CAS NO: 645-35-2
• Molecular Formula: C₆H₉N₃O₂*ClH
• Molecular Weight: 191.62
• EINECS: 211-438-9
• Product Categories: Amino Acids;Amino AcidsAlphabetic;Amino Acids, Peptides and Proteins;H;HA -HT;Life Sciences Standards
• Mol File: 645-35-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 243-244 °C(Solv: ethanol (64-17-5))
• Boiling Point: 458.9 °C at 760 mmHg
• Flash Point: 231.3 °C
• Appearance: /Crystalline
• Density: 1.472[at 20℃]
• Vapor Pressure: 3.25E-09mmHg at 25°C
• Storage Temp.: 2-8°C
• Water Solubility: 149.55g/L at 20℃
• BRN: 4168261
• CAS DataBase Reference: L-Histidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Histidine hydrochloride(645-35-2)
• EPA Substance Registry System: L-Histidine hydrochloride(645-35-2)

Safety Data

• Safety Statements: 22-24/25:
• RIDADR: UN 1789 8/PG 3
• WGK Germany: 2
• F: 10
• Hazardous Substances Data: 645-35-2(Hazardous Substances Data)

Usage

Description

L-Histidine hydrochloride can undergo racemization due to heating in water, leading to the formation of DL-histidine. It can be used as a supplement in conditions of riboflavin vitamin deficiency.

Chemical Properties

White needles, plates, or crystalline powder; slightly bitter taste. Decomp 250C. Sol in water; insol in alc, ether.

Uses

Amino acid.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C6H9N3O2.ClH/c7-5(6(10)11)1-4-2-8-3-9-4;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H

Upstream product

• 6459-59-2 histidine hydrochloride 
• 71-00-1 L-histidine 
• 71-00-1 L-histidine 

Downstream Products

• 18684-16-7 methyl (2S)-2-amino-3-(1H-imidazol-5-yl)propanoate hydrochloride 
• 7389-87-9 L-histidine methyl ester dihydrochloride 
• 1499-46-3 L-Histidine methyl ester 
• 77504-36-0 2-amino-3-((4-((S)-2-amino-2-carboxyethyl)-1H-imidazol-2-yl)thio)propionic acid 
• 79458-92-7 N-(Benzyloxycarbonyl-L-ananyl)-L-histidine 
• 105158-70-1 2,5-diiodo-L-histidine ; hydrochloride 
• 6459-59-2 histidine hydrochloride 
• 2002-22-4 (2S)-2-amino-3-(2-mercapto-1H-imidazol-4-yl)propanoic acid 
• 86895-18-3 Boc-Cys(MBzl)-Ala-Gly-His-OH 
• 24593-59-7 L-histidine benzyl ester di-para-toluene sulfonate 
• 25303-09-7 (RS),(S)-histopine 
• 20866-46-0 N,1'-bis[(1,1-dimethylethoxy)carbonyl]-L-histidine 
• 14997-58-1 N-[(benzyloxy)carbonyl]-L-histidine 
• 18502-05-1 4-cyanomethylimidazole 

Relevant articles and documents

Crystal studies, vibrational spectra and non-linear optical properties of l-histidine chloride monohydrate

This paper presents the results of our calculations on the geometric parameters, vibrational spectra and hyperpolarizability of a non-linear optical material l-histidine chloride monohydrate. Due to the lack of sufficiently precise information on geometri

Resolution of DL-racemic mixtures

The present invention relates to a process for the resolution of DL-racemic mixtures of compounds which crystalize in the form of a conglumerate. Both, the D and L-enantiomers are obtained according to the invention in a industrially feasable process by adding chiral enantioselective polymers to the supersaturated solution of the racemat to inhibit crystalization of one enantiomer. Next a DL-racemic mixture of said compound is suspended in about twice the amount of the crystallized enantiomer. Consequently, the opposite enantiomer could be recovered by said suspension by physical separation.

Design of Polymeric Inhibitors for the Control of Crystal Polymorphism. Induced Enantiomeric Resolution of Racemic Histidine by Crystallization at 25 deg C

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