64500-73-8

Basic information

• Product Name: 3-Quinolinecarbonitrile, 1,2,5,6,7,8-hexahydro-2,5-dioxo-7-phenyl-
• CAS NO: 64500-73-8
• Molecular Formula: C16H12N2O2
• Molecular Weight: 264.283
• Mol File: 64500-73-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarbonitrile, 1,2,5,6,7,8-hexahydro-2,5-dioxo-7-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarbonitrile, 1,2,5,6,7,8-hexahydro-2,5-dioxo-7-phenyl-(64500-73-8)
• EPA Substance Registry System: 3-Quinolinecarbonitrile, 1,2,5,6,7,8-hexahydro-2,5-dioxo-7-phenyl-(64500-73-8)

Safety Data

• Hazardous Substances Data: 64500-73-8(Hazardous Substances Data)

Upstream product

• 85302-08-5 2-((dimethylamino)methylene)-5-phenyl-cyclohexane-1,3-dione 
• 109-77-3 malononitrile 
• 41808-21-3 sodium salt of α-cyanoacetamide 

Relevant articles and documents

Inotropic agents. Synthesis and structure-activity relationships of new milrinone related cAMP PDE III inhibitors

The synthesis of 6-substituted 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles 1b,c, 1,2,5,6,7,8-hexahydro-2,5-dioxo-3-quinolinecarbonitriles 1d-g and esters of 5-cyano-1,6-dihydro-2-methyl-6-oxo-3-pyridinecarboxylic acid 2b-e is described. In the case of le and If, a careful elucidation of the reaction mechanism is discussed. As milrinone analogues, the above compounds were tested on contractile activity and frequency rate of spontaneously beating atria from reserpine-treated guinea pigs. The methyl and tile benzyl esters 2b and 2e showed an appreciable positive inotropic activity when compared to milrinone. A fitting study with the DISCO (Distance Comparison) model has been carried out on 2e. This modeling approach allowed for the improvement of the pharmacophoric requirements for a better interaction with the cAMP-specific PDE (PDE III), thought to be the final biological target of these cardiotonic agents.