64507-07-9

Basic information

• Product Name: 2-METHOXY-5-(TRIFLUOROMETHYL)BENZOYL CHLORIDE
• Synonyms: 2-METHOXY-5-(TRIFLUOROMETHYL)BENZOYL CHLORIDE
• CAS NO: 64507-07-9
• Molecular Formula: C₉H₆ClF₃O₂
• Molecular Weight: 238.59
• Mol File: 64507-07-9.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-METHOXY-5-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-5-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(64507-07-9)
• EPA Substance Registry System: 2-METHOXY-5-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(64507-07-9)

Safety Data

• Hazardous Substances Data: 64507-07-9(Hazardous Substances Data)

Upstream product

• 4864-01-1 2-methoxy-5-(trifluoromethyl)-benzoic acid 

Downstream Products

• 64506-92-9 β-{4-[2-(2-methoxy-5-trifluoromethylbenzamido)-ethyl]-phenyl}-propionic acid 
• 934495-04-2 Ethyl 3-[2-methoxy-5-(trifluoromethyl)phenyl]-3-oxopropanoate 
• 1065640-10-9 (Z)-tert-butyl 3-((5-tert-butyl-2-(2-methoxy-5-(trifluoromethyl)benzoylimino)thiazol-3(2H)-yl)methyl)azetidine-1-carboxylate 
• 1075243-83-2 N-[(5Z)-4-butyl-2-(2-fluoro-1,1-dimethylethyl)isothiazol-5(2H)-ylidene]-2-methoxy-5-(trifluoromethyl)benzamide 
• 1140918-01-9 N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-2-methoxy-5-(trifluoromethyl)benzamide 
• 1140917-70-9 2-methoxy-N-{2-[(2R)-tetrahydrofuran-2-ylmethyl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl}-5-(trifluoromethyl)benzamide 
• 1140918-65-5 N-(3-tert-butyl-1-((tetrahydrofuran-3-yl)methyl)-1H-pyrazol-5-yl)-2-methoxy-5-(trifluoromethyl)benzamide 
• 1187465-17-3 (Z)-N-(5-tert-butyl-3-(2-sulfamoylethyl)thiazol-2(3H)-ylidene)-2-methoxy-5-(trifluoromethyl)benzamide 
• 1416255-74-7 (2,5-dimethyl-1-benzofuran-3-yl)[2-hydroxy-5-(trifluoromethyl)phenyl]methanone 
• 1416255-32-7 (2,5-dimethyl-1-benzofuran-3-yl)[2-methoxy-5-(trifluoromethyl)phenyl]methanone 
• 933982-96-8 2-hydroxy-5-(trifluoromethyl)benzamide 

Relevant articles and documents

ARYL AND HETEROARYL-CARBOXAMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS TYK2 INHIBITORS

Novel carboxamide substituted compounds of Formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Tyrosine Kinase 2 (Tyk2).

One-Pot Domino Friedel-Crafts Acylation/Annulation between Alkynes and 2-Methoxybenzoyl Chlorides: Synthesis of 2,3-Disubstituted Chromen-4-one Derivatives

A highly regioselective synthesis of 2,3-disubstituted chromen-4-one derivatives is accomplished from readily available internal alkynes and 2-methoxybenzoyl chlorides. The reaction proceeds via a domino intermolecular Friedel-Crafts acylation/intramolecular vinyl carbocation trapping (or oxa-Michael addition)/demethylation reaction sequence. This Lewis acid promoted method features relatively mild reaction conditions to synthesize a variety of 2,3-disubstituted chromen-4-one derivatives in one pot with up to 93% yield. The chromen-2-one (coumarin) product was obtained when 2,6-dimethoxybenzoyl chloride was used as a starting material via an electrophilic aromatic substitution/rearrangement process.

Aryl hetaryl ketones and thioketones as efficient inhibitors of peptidyl-prolyl cis-trans isomerases

A series of 18 differently substituted new aryl hetaryl ketones and thioketones were synthesized in four to six steps from commercial starting materials. The new ketones were evaluated as inhibitors of the peptidyl-prolyl cis-trans isomerase hPin1 with Ki values ranging in the one-digit micromolar to sub-micromolar numbers. A crystal structure revealed the non-planar arrangement of the aryl residues at the carbonyl compound and supports the hypothesis that the new compounds might mimic the transition state of the enzymatic conversion.