645418-66-2

Basic information

• Product Name: tert-butyl 7-amino-4,4-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
• Synonyms: tert-butyl 7-amino-4,4-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate;tert-butyl 7-aMino-4,4-diMethyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate;tert-Butyl 7-Amino-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylate;7-Amino-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
• CAS NO: 645418-66-2
• Molecular Formula: C₁₆H₂₄N₂O₂
• Molecular Weight: 276.37
• Product Categories: CHIRAL CHEMICALS
• Mol File: 645418-66-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 396.795 °C at 760 mmHg
• Flash Point: 193.775 °C
• Appearance: /
• Density: 1.083 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: 2-8°C
• PKA: 4.83±0.40(Predicted)
• CAS DataBase Reference: tert-butyl 7-amino-4,4-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 7-amino-4,4-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate(645418-66-2)
• EPA Substance Registry System: tert-butyl 7-amino-4,4-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate(645418-66-2)

Safety Data

• Hazardous Substances Data: 645418-66-2(Hazardous Substances Data)

Usage

General Description

"Tert-butyl 7-amino-4,4-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate" is a chemical compound with the molecular formula C16H24N2O2. It is a derivative of 3,4-dihydroisoquinoline and contains a tert-butyl group, an amino group, and a carboxylate group. tert-butyl 7-amino-4,4-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate has potential applications in pharmaceutical research and drug development due to its structural features and potential biological activity. It may be used as a building block in the synthesis of various pharmaceutical compounds or as a research tool to study the effect of its structure on biological processes. Its specific properties and potential uses would depend on further research and testing.

InChI:InChI=1/C16H24N2O2/c1-15(2,3)20-14(19)18-9-11-8-12(17)6-7-13(11)16(4,5)10-18/h6-8H,9-10,17H2,1-5H3

Upstream product

• 453560-80-0 tert-butyl-4,4-dimethyl-7-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 442846-93-7 4,4-dimethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 645418-90-2 7-(2-amino-benzoylamino)-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 645418-65-1 7-[2-(4-fluorobenzylamino)-benzoylamino]-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 645418-73-1 7-{2-[(2-methoxy-pyridin-4-ylmethyl)-amino]-benzoylamino}-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 645419-07-4 tert-butyl 4,4-dimethyl-7-{2-[1-(2-methylamino-pyrimidin-4-yl)-ethylamino]-benzoylamino}-3,4-dihydro-1H-isoquinoline-2-carboxylate 

Relevant articles and documents

1, 2 - DIHYDRO- 3H- PYRAZOLO [3, 4 - D] PYRIMIDIN -3 - ONE ANALOGS

Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

SUBSTITUTED ANTHRANILIC AMIDE DERIVATIVES AND METHODS OF USE

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.