64596-36-7

Basic information

• Product Name: Carbamic acid, (benzoyloxy)-, phenylmethyl ester
• CAS NO: 64596-36-7
• Molecular Formula: C15H13NO4
• Molecular Weight: 271.273
• Mol File: 64596-36-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (benzoyloxy)-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (benzoyloxy)-, phenylmethyl ester(64596-36-7)
• EPA Substance Registry System: Carbamic acid, (benzoyloxy)-, phenylmethyl ester(64596-36-7)

Safety Data

• Hazardous Substances Data: 64596-36-7(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 621-84-1 O-benzyl carbamate 
• 65-85-0 benzoic acid 
• 3426-71-9 Benzyl N-hydroxycarbamate 
• 94-36-0 dibenzoyl peroxide 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

NiH-Catalyzed Proximal-Selective Hydroamination of Unactivated Alkenes

Reported herein is a modular, NiH-catalyzed system capable of proximal-selective hydroamination of unactivated alkenes with diverse amine sources. The key to the successful implementation of this approach is the promotion of NiH insertion into even highly substituted olefins via coordination of the bidentate directing group to the nickel complex. A wide range of primary and secondary amines can be installed in both internal and terminal unactivated alkenes with excellent regiocontrol under the optimized reaction conditions. This protocol is flexible and general for the preparation of a variety of valuable β- and γ-amino acid building blocks that would otherwise be difficult to synthesize. The utility of this transformation was further demonstrated by the site-selective late-stage modification of complex and medicinally relevant molecules. Combined experimental and computational studies illuminate the detailed reaction mechanism.

IMPROVED AMINOHYDROXYLATION OF ALKENES

The invention relates to a process for the aminohydroxylation of alkenes using N-oxycarbamate reagents, e.g. N-acyloxycarbamate, N-alkyloxycarbonyloxycarbamate and N-aralkoxycarbonyloxycarbamate reagents. The invention particularly relates to an intermolecular aminohydroxylation reaction that can be carried out in the absence of added base. The invention also relates to novel N-oxycarbamate reagents that are stable crystalline materials. The process of the invention is useful in the synthesis of compounds having a vicinal amino alcohol moiety, such as biologically active compounds.