64608-69-1

Basic information

• Product Name: 1H-Pyrrole-1-acetonitrile,alpha-methyl-(9CI)
• Synonyms: 1H-Pyrrole-1-acetonitrile,alpha-methyl-(9CI)
• CAS NO: 64608-69-1
• Molecular Formula: C7H8N2
• Molecular Weight: 120.154
• Product Categories: AMINETERTIARY
• Mol File: 64608-69-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrole-1-acetonitrile,alpha-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-1-acetonitrile,alpha-methyl-(9CI)(64608-69-1)
• EPA Substance Registry System: 1H-Pyrrole-1-acetonitrile,alpha-methyl-(9CI)(64608-69-1)

Safety Data

• Hazardous Substances Data: 64608-69-1(Hazardous Substances Data)

Upstream product

• 16199-06-7 potassium pyrrolide 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 72187-91-8 α-amino propionitrile hydrochloride 

Downstream Products

• 1443442-31-6 5-methyl-6,8-diphenylindolizine 
• 1443442-35-0 5,6-dimethyl-8-phenylindolizine 
• 1443442-40-7 6-(2-chlorophenyl)-8-(4-fluorophenyl)-5-methylindolizine 
• 1443442-34-9 5,8-dimethyl-6-phenylindolizine 
• 1443442-36-1 ethyl 5-methyl-6,8-diphenylindolizine-7-carboxylate 
• 1443442-41-8 6-(3,4-dimethoxyphenyl)-8-(furan-2-yl)-5-methylindolizine 
• 1443442-42-9 8-tert-butyl-6-(4-chlorophenyl)-5-methylindolizine 
• 1443442-44-1 6,7-bis(3,4-dimethoxyphenyl)-5-methylindolizine 

Relevant articles and documents

One-pot synthesis of polysubstituted indolizines by an addition/ cycloaromatization sequence

Indolizines carrying various substituents in positions 5-8 were obtained from readily available 2-(1H-pyrrol-1-yl)nitriles and α,β-unsaturated ketones or aldehydes in a one-pot procedure. Michael addition of the deprotonated aminonitriles to the acceptors followed by acid-catalyzed electrophilic cyclization produces 5,6-dihydroindolizine-5-carbonitriles. From these stable intermediates, substituted indolizines were obtained via base-induced dehydrocyanation.