6461-07-0

Basic information

• Product Name: L-Phenylalanine, L-leucyl-, methyl ester, monohydrochloride
• CAS NO: 6461-07-0
• Molecular Formula: C16H24N2O3.ClH
• Molecular Weight: 328.839
• Mol File: 6461-07-0.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, L-leucyl-, methyl ester, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, L-leucyl-, methyl ester, monohydrochloride(6461-07-0)
• EPA Substance Registry System: L-Phenylalanine, L-leucyl-, methyl ester, monohydrochloride(6461-07-0)

Safety Data

• Hazardous Substances Data: 6461-07-0(Hazardous Substances Data)

Usage

General Description

L-Phenylalanine, L-leucyl-, methyl ester, monohydrochloride is a chemical compound that is a derivative of the amino acids phenylalanine and leucine. It is commonly used in the field of biochemistry and pharmaceuticals for various research and development purposes. L-Phenylalanine, L-leucyl-, methyl ester, monohydrochloride is a monohydrochloride salt, which means it is a salt containing one equivalent of hydrochloric acid and one equivalent of the amino acid derivative. It is known to have potential applications in the synthesis of peptide and protein-based drugs, as well as in the development of new therapeutic treatments for various diseases and medical conditions. This chemical compound is also of interest in the study of cellular processes and can be used in the creation of new drug delivery systems.

Upstream product

• 63-91-2 L-phenylalanine 
• 61-90-5 L-leucine 
• 66866-44-2 Boc-Leu-O-COO-isoBu 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 188783-08-6 N-[N-(2-benzoyl-2-ethoxycarbonylvinyl-1)-L-leucyl]-L-3-phenylalanine methyl ester 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 

Downstream Products

• 132247-14-4 (S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methylsulfanyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid methyl ester 
• 876953-59-2 (S)-2-[(S)-1-((S)-1-Methoxycarbonyl-2-phenyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1367281-24-0 (Boc)2-[12]aneN₃-CH₂CO-Leu-Phe-OCH₃ 
• 868539-96-2 (S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate 
• 868540-17-4 carfilzomib 
• 868540-16-3 (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid 
• 1140908-89-9 C₃₂H₄₄N₄O₆ 
• 1410924-85-4 methyl N-acetyl-(S)-prolyl-(S)-leucyl-(S)-phenylalaninate 
• 108456-25-3 methyl (2S,5S)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-5-isobutyl-4,7-dioxo-3,6-diazaoctanoate 
• 1414357-46-2 methyl (S)-2-{(S)-2-[2-((S)-2-{4-[(8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6Hcyclopenta[a]phenanthren-17-yl]-1H-1,2,3-triazol-1-yl}propanamido)acetamido]-4-methylpentanamido}-3-phenylpropanoate 
• 1414357-91-7 methyl (S)-2-((S)-2-{2-[(S)-2-azidopropanamido]acetamido}-4-methylpentanamido)-3-phenylpropanoate 
• 1374225-27-0 C₅₅H₉₃N₉O₁₂ 
• 1365292-35-8 L-isoseryl-L-leucyl-L-phenylalanine methyl ester hydrochloride 
• 3354-31-2 (3S,6S)-3-benzyl-6-isobutylpiperazine-2,5-dione 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF (2S)-N-((S)-1-((S)-4-METHYL-1-((R)-2-METHYL OXIRAN-2-YL)-1-OXOPENTAN-2-YLCARBAMOYL)-2-PHENYLETHYL)-2-((S)-2-(2-MORPHOLINO ACETAMIDO)-4-PHENYLBUTANAMIDO)-4-METHYLPENTANAMIDE

The present invention relates to process for the preparation of (2S)-N-((S)-l -((S)-4-methyl-1 -((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phenylethyl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)-4 -methylpentanamide represented by the following structural formula-1.

Influence of neighboring groups on the thermodynamics of hydrophobic binding: An added complex facet to the hydrophobic effect

The thermodynamic consequences of systematic modifications in a ligand side chain that binds in a shallow hydrophobic pocket, in the presence and absence of a neighboring ligand carboxylate group, were evaluated using isothermal titration calorimetry (ITC

Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors

A series of novel L-isoserine derivatives were synthesised and evaluated for their ability to inhibit aminopeptidase N (APN)/CD13. In our preliminary biological results, some of these compounds possessed a potent inhibitory activity against the APN. Within this series, compound 14b not only showed similar enzyme inhibition (IC50 of 12.2μM) compared with the positive control bestatin (half maximal inhibitory concentration (IC 50) of 7.3μM), but also had a potent antiproliferative activity against human cancer cell lines cells.