64645-30-3Relevant articles and documents
Schmidbaur, Hubert,Reber, Gabriele,Schier, Anette,Wagner, Friedrich E.,Mueller, Gerhard
, p. 143 - 150 (1988)
Synthesis, structures and anti-malaria activity of some gold(i) phosphine complexes containing seleno- and thiosemicarbazonato ligands
Molter, Anja,Rust, Joerg,Lehmann, Christian W.,Deepa, Ganesh,Chiba, Peter,Mohr, Fabian
, p. 9810 - 9820 (2011/12/03)
A series of both mono- and dinuclear gold(i) phosphine complexes containing monoanionic seleno- and thiosemicarbazones as ligands were prepared and fully characterized by spectroscopic methods and, in some cases, by single crystal X-ray diffraction. The in vitro anti-malaria activity of some of these compounds was investigated in chloroquine sensitive strains of Plasmodium falciparum. The IC50 results show that the sulfur containing compounds exhibit activity similar to that of chloroquine, whilst the selenium derivatives display only moderate anti-malaria activity.
Gold(I) complexes with bidentate tertiary phosphine ligands: Formation of annular vs. tetrahedral chelated complexes
Berners-Price, Susan J.,Sadler, Peter J.
, p. 3822 - 3827 (2008/10/08)
Titrations of gold(I) complexes [(AuCl)2(P-P)] with ligand (P-P) were studied by 31P NMR for the bidentate tertiary phosphine ligands Ph2P(CH2)nPPh2, where n = 1 (dppm), 2 (dppe), 3 (dppp), and 4 (dppb), cis-Ph2PCH=CHPPh2 (dppey), Ph2P(CH2)2PEt2 (eppe), and Et2P(CH2)2PEt2 (depe). Bis-chelated four-coordinate gold(I) phosphine complexes [Au(P-P)2]+ containing either five- or six-membered chelate rings (n = 2 or 3) all exhibited exceptionally high thermodynamic and kinetic stabilities in solution. The species containing phenyl-substituted phosphines existed in CDCl3 solutions at Au:P-P ratios of less than 1:1. They were isolated and characterized with Cl- as the counteranion. [Au(depe)2]+ existed in solution at Au:depe ratios >1:1 and was isolable as a PF6- or SbF6- salt. Four-coordinate complexes containing either four- (n = 1) or seven-membered (n = 4) chelate rings were not observed as stable species in CDCl3 solutions. The solution behavior of species with a 1:1 Au:P-P ratio was also investigated by 31P NMR. In D2O the 31P NMR spectrum of the 1:1 Au:eppe species consisted of two overlapping AA′BB′ multiplets corresponding to the two isomers of the annular complex [Au2(eppe)2]2+. The isomer containing two Et2P-Au-PPh2 linkages (X) predominated by 2:1 over the other isomer (Y). For the ligands dppe and eppe, the 1:1 Au:P-P complexes were stable in aqueous solution but were involved in dissociative equilibria in CDCl3 with ring-closed species. The analogous complexes of depe, dppm, and dppb appeared to be stable in chloroform. These observations are discussed in terms of a destabilization of the annular [Au2(P-P)2]2+ complexes by steric effects.