64678-90-6Relevant articles and documents
Synthesis, fluorescence properties, and antiproliferative potential of several 3-oxo-3H-benzo[f]chromene-2-carboxylic acid derivatives
Fu, Xiao-Bo,Wang, Xian-Fu,Chen, Jia-Nian,Wu, De-Wen,Li, Ting,Shen, Xing-Can,Qin, Jiang-Ke
, p. 18565 - 18584 (2015)
In this study, two series of 3-oxo-3H-benzo[f]chromene-2-carboxylic acid derivatives (compounds 5a-i and 6a-g) were synthesized. Their in vitro proliferation inhibitory activities against the A549 and NCI-H460 human non-small cell lung cancer (NSCLC) cell lines were evaluated. Their photophysical properties were measured. Among these target compounds, 5e exhibited the strongest antiproliferative activity by inducing apoptosis, arresting cell cycle, and elevating intracellular reactive oxygen species (ROS) level, suggesting that it may be a potent antitumor agent. In addition, compound 6g with very low cytotoxicity, demonstrated excellent fluorescence properties, which could be used as an effective fluorescence probe for biological imaging.
Photolysis of Acyl Azides Leading to Acyl Nitrenes
Elkasaby, M. A.,Noureldin, N. A.
, p. 1080 - 1081 (2007/10/02)
Photolysis of acyl azides is shown to give acyl nitrenes in the triplet state and not in the single state.The acyl nitrenes have been trapped by hydrocarbons and aniline.