64695-96-1Relevant articles and documents
ALK KINASE INHIBITOR, AND PREPARATION METHOD AND USE THEREOF
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Paragraph 0106; 0107; 0108; 0109; 0110; 0111, (2017/04/18)
An ALK kinase inhibitor compound as represented by Formula I, pharmaceutical composition containing the compound, and preparation method and use thereof in the preparation of drugs serving as an ALK inhibitor for treating cancer.
PROCESS FOR PREPARATION OF CERITINIB
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Page/Page column 44, (2016/12/26)
The present application relates to a process for preparation of ceritinib and intermediates thereof. Specifically, the present application relates to a process for preparation of N-(4-(1-benzyl- 1,2,3,6-tetrahydropyridin-4-yl)-2-isopropoxy-5-methylphenyl)acetamide (VC) comprising treating N-(4-(bromomethyl)-2-isopropoxy-5-methylphenyl)acetamide (IIID) with 1- benzylpiperidin-4-one (IVA). The present application also relates to a process for conversion of N-(4-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-2-isopropoxy-5-methylphenyl)-acetamide (VC) to ceritinib or an acid-addition salt thereof.
Fluorinated tricyclic neuroleptics: 6,7 Difluoro derivative of chlorprothixene and 2-fluoro-3-hydroxy derivative of octoclothepin
Cervena,Sindelar,Kopicova,et al.
, p. 2001 - 2017 (2007/10/05)
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