647028-80-6

Basic information

• Product Name: L-Serine, O-2-propenyl-N-(triphenylmethyl)-, methyl ester
• CAS NO: 647028-80-6
• Molecular Formula: C26H27NO3
• Molecular Weight: 401.505
• Mol File: 647028-80-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: L-Serine, O-2-propenyl-N-(triphenylmethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Serine, O-2-propenyl-N-(triphenylmethyl)-, methyl ester(647028-80-6)
• EPA Substance Registry System: L-Serine, O-2-propenyl-N-(triphenylmethyl)-, methyl ester(647028-80-6)

Safety Data

• Hazardous Substances Data: 647028-80-6(Hazardous Substances Data)

Upstream product

• 13515-76-9 methyl N-trityl-L-serinate 
• 106-95-6 allyl bromide 
• 76-83-5 trityl chloride 

Downstream Products

• 647028-62-4 (2S,3R)-2-[5-[6-(N-tert-butyldimethylsilylcarbamoyloxy)-3-tert-butyldimethylsilyloxy-4-hexynyl]oxazol-2-yl]-3-iodomethyl-1-tritylaziridine 
• 647028-66-8 (2S,3R)-2-[5-[3,6-bis-(tert-butyldimethylsilyloxy)-4-hexynyl]oxazol-2-yl]-3-iodomethyl-1-tritylaziridine 
• 647028-92-0 (2S,3R)-2-[5-[3-acetoxy-6-tert-butyldimethylsilyloxy-1-methyl-4-hexynyl]oxazol-2-yl]-3-iodomethyl-1-tritylaziridine 
• 647028-65-7 (2S,3R)-2-[5-[3-acetoxy-6-(tert-butyldimethylsilyloxy)-4-hexynyl]oxazol-2-yl]-3-iodomethyl-1-tritylaziridine 
• 647028-95-3 (2S,3R)-2-[5-[6-(tert-butyldimethylsilyloxy)-3-hydroxy-4-hexynyl]oxazol-2-yl]-3-iodomethyl-1-tritylaziridine 
• 647028-91-9 Carbamic acid 4-hydroxy-6-[2-((2S,3R)-3-iodomethyl-1-trityl-aziridin-2-yl)-oxazol-5-yl]-hex-2-ynyl ester 
• 647028-82-8 2-[(2S,3R)-3-allyloxymethyl-1-trityl-aziridin-2-yl]-5-[(1R)-3-tert-butyldimethylsilyloxy-1-methylpropyl]oxazole 
• 647028-87-3 (2S,3R)-2-(5-[3-tert-butyldimethylsilyloxy-1-methylpropyl]oxazol-2-yl)-3-iodomethyl-1-tritylaziridine 
• 647028-90-8 4-Hydroxy-6-[2-((2S,3R)-3-iodomethyl-1-trityl-aziridin-2-yl)-oxazol-5-yl]-hex-2-ynoic acid methyl ester 
• 647028-55-5 (2S,3R)-2-(5-tert-butyldimethylsilyloxypropyloxazol-2-yl)-3-iodomethyl-1-tritylaziridine 
• 647028-85-1 (2S,3R)-2-(5-tert-butyldimethylsilyloxypropyloxazol-2-yl)-3-hydroxymethyl-1-tritylaziridine 
• 647028-86-2 (2S,3R)-2-(5-[3-tert-butyldimethylsilyloxy-1-methylpropyl]oxazol-2-yl)-3-hydroxymethyl-1-tritylaziridine 
• 647028-89-5 (2S,3R)-2-(5-[3-hydroxy-1-methylpropyl]oxazol-2-yl)-3-iodomethyl-1-tritylaziridine 
• 647028-88-4 (2S,3R)-2-(hydroxypropyloxazol-2-yl)-3-iodomethyl-1-tritylaziridine 

Relevant articles and documents

Copper(I)-Mediated Denitrogenative Macrocyclization for the Synthesis of Cyclic α3β-Tetrapeptide Analogues

A copper(I)-mediated denitrogenative reaction has been successfully developed for the preparation of cyclic tetrapeptides. The key reactive intermediate, ketenimine, triggers intramolecular cyclization through attack of the terminal amine group to generate an internal β-amino acid with an amidine linkage. The chemistry developed herein provides a new synthetic route for the preparation of cyclic α3β-tetrapeptide analogues that contain important biological properties and results in rich structural information being obtained for conformational studies. With the success of this copper(I)-catalyzed macrocyclization, two histone deacetylase inhibitor analogues consisting of the cyclic α3β-tetrapeptide framework have been successfully synthesized.

Enantiocontrolled synthesis of (1S,2S)-6-desmethyl- (methylaziridino)mitosene [8]

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