64724-10-3

Basic information

• Product Name: 1-(2-Chloroethyl)tetrahydro-1H,5H-[1,3,2]diazaphospholo[2,1-b][1,3,2]oxazaphosphorine 9-Oxide
• Synonyms: 1-(2-Chloroethyl)tetrahydro-1H,5H-[1,3,2]diazaphospholo[2,1-b][1,3,2]oxazaphosphorine 9-Oxide
• CAS NO: 64724-10-3
• Molecular Formula: C7H14ClN2O2P
• Molecular Weight: 224.625021
• Product Categories: Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 64724-10-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 298.9°Cat760mmHg
• Flash Point: 134.6°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 0.00123mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: Methanol, Water
• CAS DataBase Reference: 1-(2-Chloroethyl)tetrahydro-1H,5H-[1,3,2]diazaphospholo[2,1-b][1,3,2]oxazaphosphorine 9-Oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Chloroethyl)tetrahydro-1H,5H-[1,3,2]diazaphospholo[2,1-b][1,3,2]oxazaphosphorine 9-Oxide(64724-10-3)
• EPA Substance Registry System: 1-(2-Chloroethyl)tetrahydro-1H,5H-[1,3,2]diazaphospholo[2,1-b][1,3,2]oxazaphosphorine 9-Oxide(64724-10-3)

Safety Data

• Hazardous Substances Data: 64724-10-3(Hazardous Substances Data)

Usage

Description

1-(2-Chloroethyl)tetrahydro-1H,5H-[1,3,2]diazaphospholo[2,1-b][1,3,2]oxazaphosphorine 9-Oxide is a cyclophosphamide derivative, which is a degradation product of cyclophosphamide synthesis with significant antitumor activity. 1-(2-Chloroethyl)tetrahydro-1H,5H-[1,3,2]diazaphospholo[2,1-b][1,3,2]oxazaphosphorine 9-Oxide is characterized by its yellow solid appearance and is recognized for its potential applications in the medical field due to its anti-cancer properties.

Uses

Used in Pharmaceutical Industry:
1-(2-Chloroethyl)tetrahydro-1H,5H-[1,3,2]diazaphospholo[2,1-b][1,3,2]oxazaphosphorine 9-Oxide is used as an active pharmaceutical ingredient for its antitumor properties. 1-(2-Chloroethyl)tetrahydro-1H,5H-[1,3,2]diazaphospholo[2,1-b][1,3,2]oxazaphosphorine 9-Oxide is particularly effective against various types of cancer due to its ability to interfere with the cell cycle and DNA synthesis, leading to the destruction of cancerous cells.
Used in Cancer Research:
In the field of cancer research, 1-(2-Chloroethyl)tetrahydro-1H,5H-[1,3,2]diazaphospholo[2,1-b][1,3,2]oxazaphosphorine 9-Oxide serves as a valuable compound for studying the mechanisms of action and potential synergistic effects when combined with other chemotherapeutic agents. This research can lead to the development of novel treatment strategies and improved cancer therapies.
Used in Drug Development:
1-(2-Chloroethyl)tetrahydro-1H,5H-[1,3,2]diazaphospholo[2,1-b][1,3,2]oxazaphosphorine 9-Oxide is utilized in the development of new drugs and drug formulations, aiming to enhance the efficacy and safety of cancer treatments. Its chemical properties and antitumor activity make it a promising candidate for the creation of innovative pharmaceutical products.

InChI:InChI=1/C7H14ClN2O2P/c8-2-4-10-6-5-9-3-1-7-12-13(9,10)11/h1-7H2

Downstream Products

• 158401-52-6 3-(2-Chloro-ethyl)-2-oxo-2λ⁵-[1,3,6,2]oxadiazaphosphonan-2-ol 
• 45164-26-9 Phosphoric acid mono-{3-[2-(2-chloro-ethylamino)-ethylamino]-propyl} ester