64739-80-6Relevant articles and documents
Synthesis of isomeric 1,4-[13C]2-labeled 2-ethoxycarbonyl-1,4-diphenylbutadienes
Crist, Rachael M.,Reddy, Pulgam Veera,Borhan, Babak
, p. 619 - 621 (2001)
The 1,4-bis-13C-labeled isomeric compounds (Z,E)- and (E,E)-2-ethoxycarbonyl-1,4-diphenylbutadiene have been synthesized by two different methods. A double Horner-Wadsworth-Emmons (HWE) strategy was employed for the synthesis of the Z,E isomer. On the other hand, synthesis of the E,E isomer was achieved by Baylis-Hillman reaction of benzaldehyde with ethyl acrylate and subsequent rearrangement, followed by Wittig olefination with benzaldehyde. The routes provide stereoselective access to labeled compounds in good yields.
