6480-68-8

Basic information

• Product Name: 3-Quinolinecarboxylic acid
• Synonyms: 3-QUINOLINECARBOXYLIC ACID;AKOS BBS-00005333;RARECHEM AL BO 1256;QUINOLINE-3-CARBOXYLIC ACID;3-Carboxyquinoline.;Quinoline-3-carboxylic acid 97%;3-Quinolinecarboxylic acid,98%;Quinoline-3-carboxylic acid ,98%
• CAS NO: 6480-68-8
• Molecular Formula: C₁₀H₇NO₂
• Molecular Weight: 173.16808
• EINECS: 229-337-3
• Product Categories: Carboxylic Acids;Quinolines, Isoquinolines & Quinoxalines;Quinoline&Isoquinoline;Quinoline Derivertives;Carboxylic Acids;Quinolines, Isoquinolines & Quinoxalines;Building Blocks;Heterocyclic Building Blocks;Quinolines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;C8 to C10;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 6480-68-8.mol
• Article Data: 18

Chemical Properties

• Melting Point: 277-280 °C(lit.)
• Boiling Point: 303.81°C (rough estimate)
• Flash Point: 164.7 °C
• Appearance: White to slightly beige/Powder
• Density: 1.2427 (rough estimate)
• Vapor Pressure: 1.85E-05mmHg at 25°C
• Refractive Index: 1.5200 (estimate)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 2.20±0.30(Predicted)
• BRN: 126542
• CAS DataBase Reference: 3-Quinolinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxylic acid(6480-68-8)
• EPA Substance Registry System: 3-Quinolinecarboxylic acid(6480-68-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36/38
• Safety Statements: 22-24/25-37/39-26-37
• WGK Germany: 3
• Hazardous Substances Data: 6480-68-8(Hazardous Substances Data)

Usage

Description

3-Quinolinecarboxylic acid is a quinoline derivative characterized by its antimicrobial properties. It is a white to slightly beige powder, which has been evaluated for its antibacterial activity.

Uses

Used in Pharmaceutical Industry:
3-Quinolinecarboxylic acid is used as an antimicrobial agent for its ability to inhibit the growth of various bacteria. This makes it a valuable compound in the development of new drugs and treatments for bacterial infections.
Used in Research and Development:
In the field of research and development, 3-Quinolinecarboxylic acid serves as a key compound for studying its potential applications in medicine and other industries. Its antimicrobial properties make it an interesting subject for further investigation into its effectiveness against different types of bacteria and possible integration into various products.
Used in Agricultural Industry:
3-Quinolinecarboxylic acid can also be utilized in the agricultural industry as a potential antimicrobial agent to protect crops from bacterial infections, thereby increasing yield and reducing the need for chemical pesticides.
Used in Cosmetics Industry:
Due to its antimicrobial properties, 3-Quinolinecarboxylic acid can be employed in the cosmetics industry as a preservative to extend the shelf life of products and maintain their safety and efficacy.

InChI:InChI=1/C10H7NO2/c12-10(13)8-5-7-3-1-2-4-9(7)11-6-8/h1-6H,(H,12,13)/p-1

Upstream product

• 612-58-8 3-methylquinoline 
• 1873-54-7 3-ethyl quinoline 
• 5332-24-1 3-bromoquinoline 
• 34846-64-5 3-cyanoquinoline 
• 33021-53-3 1-quinolin-3-yl-ethanone 
• 4945-38-4 2-hydroxymethylquinoline-3-carboxylic acid lactone 
• 13669-42-6 3-quinolylcarboxaldehyde 
• 124-38-9 carbon dioxide 
• 529-23-7 o-aminobenzaldehyde 
• 201230-82-2 carbon monoxide 
• 17609-48-2 (R)-2-phenylglycine ethyl ester hydrochloride 
• 120277-70-5 3-(bromomethyl)quinoline 
• 590-29-4 potassium formate 
• 584-08-7 potassium carbonate 

Downstream Products

• 50741-46-3 ethyl 3-quinolinecarboxylate 
• 84741-86-6 quinoline-3-carbonyl chloride 
• 102022-20-8 [3]quinolyl-mesityl ketone 
• 104637-19-6 N-(3-Chinolincarbonyl)-N-methyl-phenylglycinamid 
• 138354-46-8 Quinoline-3-carboxylic acid (3,3-diphenyl-allyl)-amide 
• 127368-41-6 Quinoline-3-carboxylic acid [(R)-1-benzylcarbamoyl-2-(1H-indol-3-yl)-ethyl]-amide 
• 127368-59-6 Quinoline-3-carboxylic acid [(R)-1-(benzyl-methyl-carbamoyl)-2-(1H-indol-3-yl)-ethyl]-amide 
• 127368-56-3 (Benzyl-{(R)-3-(1H-indol-3-yl)-2-[(quinoline-3-carbonyl)-amino]-propionyl}-amino)-acetic acid ethyl ester 
• 127368-52-9 Quinoline-3-carboxylic acid [2-(5-benzyloxy-1H-indol-3-yl)-1-dipentylcarbamoyl-ethyl]-amide 
• 127368-63-2 Quinoline-3-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-((R)-1-phenyl-ethylcarbamoyl)-ethyl]-amide 
• 136675-73-5 Quinoline-3-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-amide 
• 136631-70-4 {(R)-3-(1H-Indol-3-yl)-2-[(quinoline-3-carbonyl)-amino]-propionylamino}-phenyl-acetic acid ethyl ester 
• 136631-71-5 (R)-{(R)-3-(1H-Indol-3-yl)-2-[(quinoline-3-carbonyl)-amino]-propionylamino}-phenyl-acetic acid ethyl ester 
• 124502-70-1 Quinoline-3-carboxylic acid [4-(4-benzhydryl-piperazin-1-yl)-butyl]-amide 

Relevant articles and documents

Method for preparing aromatic carboxylic acid compound

The invention discloses a method for preparing an aromatic carboxylic acid compound. The method comprises the following steps: 1) heating carbon dioxide and hydrosilane in the presence of a copper catalyst in a reaction medium A; and 2) adding a reaction medium B, aryl halide, a palladium catalyst and a base to the reaction mixture in the step 1), sealing the reaction system, and performing a heating reaction. The method has the advantages that raw materials are simple and easy to obtain, the raw materials are cheap and stable, the catalyst is common, easy to obtain and stable, the reaction conditionsaremild, the aftertreatment is simple, the yield is high, and the like.

Nickel-catalyzed carboxylation of aryl and heteroaryl fluorosulfates using carbon dioxide

The development of efficient and practical methods to construct carboxylic acids using CO2 as a C1 synthon is of great importance. Nickel-catalyzed carboxylation of aryl fluorosulfates and heteroaryl fluorosulfates with CO2 is described, affording arene carboxylic acids with good to excellent yields under mild conditions. In addition, a one-pot phenol fluorosulfation/carboxylation is developed.

Tandem one-pot CO2 reduction by PMHS and silyloxycarbonylation of aryl/vinyl halides to access carboxylic acids

The present study discloses the synthesis of aryl/vinyl carboxylic acids from Csp2-bound halides (Cl, Br, I) in a carbonylative path by using silyl formate (from CO2 and hydrosilane) as an instant CO-surrogate. Hydrosilane provides hydride for reduction and its oxidation product silanol serves as a coupling partner. Mono-, di-, and tri-carboxylic acids were obtained from the corresponding aryl/vinyl halides.