64820-41-3Relevant articles and documents
Design, synthesis, and antiviral activities of 1,5-benzothiazepine derivatives containing pyridine moiety
Li, Tianxian,Zhang, Jian,Pan, Jianke,Wu, Zengxue,Hu, Deyu,Song, Baoan
, p. 657 - 662 (2016/10/14)
In our previous work, a series of novel benzothiazepine derivatives containing pyridine moiety were successfully synthesized through chalcone 1,3-dipolar cycloaddition and determined their antiviral activity against tobacco mosaic virus (TMV). Bioassay results indicated that most of these target compounds exhibited improved curative, protection, and inactivation activity in?vivo than the commercial agent ningnanmycin. Particularly, compound 3m exhibited marked curative activity against TMV, with an EC50value of 352.2?μM, which was even better than that of ningnanmycin. The compound was identified as the most promising candidate for inhibiting plant virus and an excellent compound with antiviral activities against TMV. Structure–activity relationship experiment indicated that the 1,5-benzothiazepine moiety is crucial for potent anti-TMV activity.
Facile synthesis of 1,5-benzothiazepines in water using tetrabutylammonium tribromide
Yan, Yunhui,Yang, Xiaojuan,Wu, Liqiang
experimental part, p. 573 - 579 (2012/06/01)
A simple, environmentally benign, and efficient method was developed for the preparation of 1,5-benzothiazepines via a one-pot condensation reaction of 2-aminothiophenol with 1,3-diaryl-2-propenones using tetrabutylammonium tribromide as an efficient and versatile catalyst in water.
Synthesis of 1,5-benzothiazepines with microwave irradiation under solvent and catalyst-free conditions
Rahman,Roy,Majee,Hajra
experimental part, p. 178 - 179 (2010/02/28)
Microwave irradiation of a,β-unsaturated ketones (chalcones) and o-aminothiophenol in the absence of solvent and catalyst provides a highly efficient methodology for the synthesis of 1,5-benzothiazepines in moderate to good yields.
