64820-66-2

Basic information

• Product Name: 6-chloro-4-phenyl-3,4-dihydro-1H-quinazolin-2-one
• CAS NO: 64820-66-2
• Molecular Weight: 258.707
• Mol File: 64820-66-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-chloro-4-phenyl-3,4-dihydro-1H-quinazolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-4-phenyl-3,4-dihydro-1H-quinazolin-2-one(64820-66-2)
• EPA Substance Registry System: 6-chloro-4-phenyl-3,4-dihydro-1H-quinazolin-2-one(64820-66-2)

Safety Data

• Hazardous Substances Data: 64820-66-2(Hazardous Substances Data)

Upstream product

• 57-13-6 urea 
• 1159372-20-9 (2-amino-5-chlorophenyl)(phenyl)methanol 
• 5922-60-1 2-amino-5-chlorobenzonitrile 
• 108-86-1 bromobenzene 
• 719-59-5 5-chloro-2-aminobenzophenone 

Relevant articles and documents

Ureas in Organic Synthesis. XII. Syntesis of 2-Amino-5-chlorobenzhydrylureas and Their Heterocyclization

A synthetic method was developed for hard-to-get biologically active 2-amino-5-chlorobenzhydrylureas based on reaction of the corresponding benzhydrols with urea in sulfuric acid. The 2-amino-5-chlorobenzhydrylureas were shown to easily undergo on heating cyclization to 1-R-1,2,3,4-tetrahydro-4-phenyl-chloroquinazolin-2-ones.

SYNTHESIS OF QUINAZOLINES

Grignard reagents reacted with 2-aminobenzonitrile to give the intermediate (10), which readily could be cyclized to quinazolines by reaction with carbonyl compounds (e.g. acid chlorides, anhydrides, formates and oxalates).The intermediate (10) and aldehy