64835-42-3

Basic information

• Product Name: Benzenesulfonyl chloride, 2,4-dimethyl-6-nitro-
• CAS NO: 64835-42-3
• Molecular Formula: C8H8ClNO4S
• Molecular Weight: 249.675
• Mol File: 64835-42-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzenesulfonyl chloride, 2,4-dimethyl-6-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonyl chloride, 2,4-dimethyl-6-nitro-(64835-42-3)
• EPA Substance Registry System: Benzenesulfonyl chloride, 2,4-dimethyl-6-nitro-(64835-42-3)

Safety Data

• Hazardous Substances Data: 64835-42-3(Hazardous Substances Data)

Upstream product

• 606-38-2 N-(2,4-dimethyl-6-nitro-phenyl)-acetamide 
• 1635-84-3 2,4-Dimethyl-6-nitroanilin 

Downstream Products

• 1110273-50-1 2,4-dimethyl-N-[(S)-2-methyl-1-(3-methylindol-1-ylmethyl)propyl]-6-nitrobenzenesulfonamide 
• 1110273-47-6 N-((S)-2-hydroxy-1-methylethyl)-2,4-dimethyl-6-nitrobenzenesulfonamide 

Relevant articles and documents

Glucocorticoid Mimetics, Methods of Making Them, Pharmaceutical Compositions and Uses Thereof

Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

Studies of Reactions of Amines with Sulfur Trioxide. VI. Thermal Reactions of Anilinium, Dimethylanilinium, and Trimethylanilinium Salts of Butylamidosulfuric Acid

When the title compounds were heated in an evacuated reaction vessel, both transsulfonation and rearrangement occurred.At lower temperatures (80-120 deg C) the corresponding phenylamidosulfates and sulfophenylamidosulfates (transsulfonation products) were the main products.Increasing temperature led to the formation of ring mono- and disulfonates (rearrangement products) at the expense of the transsulfonation products.The sulfonate group always migrated to the ortho and/or para position(s) to the amino group.In no case was any meta-product detected.There was no significant difference in the ease of transsulfonation among the anilinium salts studied exept 2,6-dimethyl- and 2,4,6-trimethylanilinium salts.On the other hand, the ease of rearrangement and the orientation of ring sulfonation depended strongly on the structure of the substrate anilines.The thermal reactions of 2,4,6-trimethylanilinium butylamidosulfate produced (2,4,6-trimethylphenylimido)bis(sulfate) in addition to (2,4,6-trimethylphenylamido)sulfate.This is the first isolation of an arylimidobis(sulfate) from such reactions.Mechanisms of the transsulfonation and rearrangement have been discussed.