64845-67-6

Basic information

• Product Name: 7,8-dehydro-9,10-desacetyldoxorubicinone
• Synonyms: 7,8-dehydro-9,10-desacetyldoxorubicinone;6,8,11-Trihydroxy-1-Methoxy-5,12-naphthacenedione;Doxorubicin IMpurity 2;6,8,11-Trihydroxy-1-Methoxy-5,12-naphthacenedione (Doxorubicin IMpurity)
• CAS NO: 64845-67-6
• Molecular Formula: C19H12O6
• Molecular Weight: 336.29498
• Product Categories: Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 64845-67-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 671.6°C at 760 mmHg
• Flash Point: 251.5°C
• Appearance: /
• Density: 1.582g/cm³
• Vapor Pressure: 1.18E-18mmHg at 25°C
• Refractive Index: 1.776
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 7.59±0.20(Predicted)
• CAS DataBase Reference: 7,8-dehydro-9,10-desacetyldoxorubicinone(CAS DataBase Reference)
• NIST Chemistry Reference: 7,8-dehydro-9,10-desacetyldoxorubicinone(64845-67-6)
• EPA Substance Registry System: 7,8-dehydro-9,10-desacetyldoxorubicinone(64845-67-6)

Safety Data

• Hazardous Substances Data: 64845-67-6(Hazardous Substances Data)

Usage

Description

7,8-dehydro-9,10-desacetyldoxorubicinone is an impurity derived from the antineoplastic agent Doxorubicin (D558000). It is a red solid with specific chemical properties that differentiate it from the parent compound.

Uses

Used in Pharmaceutical Industry:
7,8-dehydro-9,10-desacetyldoxorubicinone is used as an impurity in the production of the antineoplastic agent Doxorubicin. Its presence may affect the efficacy and safety profile of the drug, making it important to monitor and control its levels during the manufacturing process.
Used in Research and Development:
In the field of pharmaceutical research and development, 7,8-dehydro-9,10-desacetyldoxorubicinone can be used as a subject of study to understand its chemical properties, potential interactions with other compounds, and any possible effects on the overall pharmacological activity of Doxorubicin.
Used in Quality Control:
7,8-dehydro-9,10-desacetyldoxorubicinone is used as a reference compound in quality control processes to ensure the purity and potency of Doxorubicin. By analyzing the levels of this impurity, manufacturers can maintain the quality standards of the final product and ensure patient safety.
Used in Toxicology Studies:
As an impurity of Doxorubicin, 7,8-dehydro-9,10-desacetyldoxorubicinone may be involved in toxicology studies to evaluate its potential adverse effects on human health. Understanding the toxicological profile of this compound can contribute to the overall safety assessment of Doxorubicin.
Used in Environmental Monitoring:
In the context of environmental monitoring, 7,8-dehydro-9,10-desacetyldoxorubicinone may be used as a marker to track the release and distribution of Doxorubicin or its byproducts in the environment, particularly in areas where the drug is manufactured or used.

InChI:InChI=1/C19H12O6/c1-25-12-4-2-3-10-13(12)19(24)15-14(17(10)22)18(23)11-7-8(20)5-6-9(11)16(15)21/h2-7,20-21,23H,1H3

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