64889-55-0

Basic information

• Product Name: Acetamide, 2,2,2-trifluoro-N-[1-(hydroxymethyl)-2-phenylethyl]-, (S)-
• CAS NO: 64889-55-0
• Molecular Formula: C11H12F3NO2
• Molecular Weight: 247.217
• Mol File: 64889-55-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Acetamide, 2,2,2-trifluoro-N-[1-(hydroxymethyl)-2-phenylethyl]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2,2,2-trifluoro-N-[1-(hydroxymethyl)-2-phenylethyl]-, (S)-(64889-55-0)
• EPA Substance Registry System: Acetamide, 2,2,2-trifluoro-N-[1-(hydroxymethyl)-2-phenylethyl]-, (S)-(64889-55-0)

Safety Data

• Hazardous Substances Data: 64889-55-0(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 536-74-3 phenylacetylene 
• 109-00-2 3-HYDROXYPYRIDINE 
• 1366341-46-9 (S)-4-benzyl-2-trifluoromethyl-1,3-oxazoline 
• 135-19-3 β-naphthol 
• 150-76-5 4-methoxy-phenol 
• 100-02-7 4-nitro-phenol 
• 108-95-2 phenol 
• 22325-27-5 4,6-dimethyl-2-meraptopyrimidine 
• 3182-95-4 L-Phenylalaninol 
• 76-05-1 trifluoroacetic acid 
• 383-63-1 ethyl trifluoroacetate, 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 118433-76-4 C₁₈H₁₈F₃NO₄S 
• 1258847-31-2 (S)-()-2,2,2-trifluoro-N-(1-iodo-3-phenylpropan-2-yl)acetamide 
• 1431213-91-0 N-((S)-3-chloro-1-phenylpropan-2-yl)-2,2,2-trifluoroacetamide 

Relevant articles and documents

Taking control of P1, P1′ and double bond stereochemistry in the synthesis of Phe-Phe (E)-alkene amide isostere dipeptidomimetics

A protocol for the stereocontrolled independent preparation of Phe-Phe trans-vinyl amide isostere dipeptideomimetics was developed based on a Wittig-type reaction. In the reaction two chiral building blocks were joined with excellent E-selectivity to give

Asymmetric hydroformylation of Z -Enamides and enol esters with rhodium-bisdiazaphos catalysts

Asymmetric hydroformylation (AHF) of Z-enamides and Z-enol esters provides chiral, alpha-functionalized aldehydes with high selectivity and atom economy. Rh-bisdiazaphospholane catalysts enable hydroformylation of these challenging disubstituted substrates under mild reaction conditions and low catalyst loadings. The synthesis of a protected analog of l-DOPA demonstrates the utility of AHF for enantioselective, atom-efficient synthesis of peptide precursors.

A facile one-pot synthesis of 2-fluoroalkyl 1,3-imidazolines and 1,3-oxazolines through imidoyl halide intermediates

A facile one-pot procedure has been developed for the synthesis of 1,3-imidazolines and 1,3-oxazolines bearing fluorinated alkyl groups at the 2-position. The reaction involves the condensation of N-monosubstituted ethane-1,2-diamines or 2-aminoethanols with a fluorinated carboxylic acid in the presence of PPh3/CX4. The proposed mechanism is that the amide intermediates were initially formed, and then converted to the imidoyl halide intermediates in the presence of PPh3/CX4, followed by rapid intramolecular cyclization to 1,3-diazoline products. This protocol allows for the synthesis of 2-bromodifluoromethyl-1,3-imidazoline, a useful CF2Br-heterocyclic building block, which can be used for the synthesis of gem-difluoromethylene linked compounds.