6491-25-4

Basic information

• Product Name: H-GLY-ALA-ALA-OH
• Synonyms: H-GLY-ALA-ALA-OH;GLY-ALA-ALA;GLYCYL-L-ALANYL-L-ALANINE
• CAS NO: 6491-25-4
• Molecular Formula: C8H15N3O4
• Molecular Weight: 217.22
• Product Categories: Amino Acid Derivatives
• Mol File: 6491-25-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: H-GLY-ALA-ALA-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-GLY-ALA-ALA-OH(6491-25-4)
• EPA Substance Registry System: H-GLY-ALA-ALA-OH(6491-25-4)

Safety Data

• Hazardous Substances Data: 6491-25-4(Hazardous Substances Data)

Usage

General Description

H-GLY-ALA-ALA-OH, also known as glycylalaninealanine, is a chemical compound consisting of three amino acids linked together. Glycine, the simplest amino acid, is followed by two molecules of alanine. H-GLY-ALA-ALA-OH is commonly used in the study of peptide synthesis and as a building block for creating larger peptides and proteins. Its structure makes it a useful tool for investigating the properties and behaviors of peptides in various biological and chemical contexts. Additionally, H-GLY-ALA-ALA-OH can also be used in the development of pharmaceuticals and other biologically active compounds due to its role in forming peptide bonds and its potential biological activity.

Relevant articles and documents

Methyl group steric effects on the kinetics of the copper(II)-tripeptide reactions with triethylenetetramine

Rates of reaction of triethylenetetramine (trien) with doubly deprotonated (tripeptido)cuprate(II) complexes are measured as a function of the number and position of methyl groups in the amino acid residues. Twelve tripeptides that consist of glycyl (G), L-alanyl (A), and α-aminoisobutyryl (Aib) residues are compared. The Cu(H-2Aib3)- complex reacts 8 orders of magnitude more slowly with trien than does the Cu(H-2G3)- complex. Methyl groups on the α-carbon of the second and third amino acid residues (from the amino terminus) decrease the rate of the trien substitution reaction to a much greater extent than methyl groups on the first residue. An empirical correlation between the second-order rate constant (Ktrien, M-1 s-1 at 25.0°C, pH ? 11) and the number and position of the methyl groups is found: log ktrien = 6.7 - 0.2C1 - 2.2C2 - 1.6C3, where Ci denotes the number of methyl groups in the ith amino acid residue. The enormous changes in reactivity are attributed primarily to steric effects in these ligand-ligand exchange reactions.