64957-09-1

Basic information

• Product Name: N,N'-bis(benzyloxycarbonyl)-L-cystine dibenzyl ester
• Synonyms: N,N'-bis(benzyloxycarbonyl)-L-cystine dibenzyl ester
• CAS NO: 64957-09-1
• Molecular Weight: 688.822
• Mol File: 64957-09-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N,N'-bis(benzyloxycarbonyl)-L-cystine dibenzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-bis(benzyloxycarbonyl)-L-cystine dibenzyl ester(64957-09-1)
• EPA Substance Registry System: N,N'-bis(benzyloxycarbonyl)-L-cystine dibenzyl ester(64957-09-1)

Safety Data

• Hazardous Substances Data: 64957-09-1(Hazardous Substances Data)

Upstream product

• 6968-11-2 N,N'-bis(benzyloxycarbonyl)-L-cystine 
• 100-39-0 benzyl bromide 
• 83824-80-0 benzyl (2S)-1-benzyloxycarbonyl-aziridine-2-carboxylate 
• 501-53-1 benzyl chloroformate 
• 21209-51-8 N-benzyloxycarbonyl-L-serine benzyl ester 
• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 
• 16938-05-9 (S)-N-(benzyloxycarbonyl)-O-(p-toluenesulfonyl)serine benzyl ester 
• 100-51-6 benzyl alcohol 
• 84697-17-6 L-Cystine dibenzyl ester dihydrochloride 
• 40470-28-8 N.N'-bis-benzyloxycarbonyl-L-cystyl dichloride 
• 104-15-4 toluene-4-sulfonic acid 

Downstream Products

• 64957-10-4 (R)-2-Benzyloxycarbonylamino-3-ethoxysulfonyl-propionic acid benzyl ester 
• 64957-08-0 (R)-benzyl 2-(benzyloxycarbonylamino)-3-(chlorosulfonyl)propanoate 
• 86123-07-1 Z-Cys-OBzl 

Relevant articles and documents

Highly Selective Sub-Nanomolar Cathepsin S Inhibitors by Merging Fragment Binders with Nitrile Inhibitors

Pharmacological inhibition of cathepsin S (CatS) allows for a specific modulation of the adaptive immune system and many major diseases. Here, we used NMR fragment screening and crystal structure-aided merging to synthesize novel, highly selective CatS inhibitors with picomolar enzymatic Ki values and nanomolar functional activity in human Raji cells. Noncovalent fragment hits revealed binding hotspots, while the covalent inhibitor structure-activity relationship enabled efficient potency optimization.

Galloyl-derived orthoquinones as reactive partners in nucleophilic additions and Diels-Alder dimerizations: A novel route to the dehydrodigalloyl linker unit of agrimoniin-type ellagitannins

Orthochloranil-mediated oxidation of galloyl monoethers furnishes the derived orthoquinones in excellent yield. These reactive electrophiles participate in a variety of nucleophilic addition reactions with heteroatomic and carbanionic partners. In addition, Lewis acid-mediated dimerization of the orthoquinones provides an efficient route to dehydrodigalloyl-type diaryl ether units characteristic of several ellagitannin natural products. The implications for ellagitannin biosynthesis and gallotannin-protein covalent attachment are discussed.