64959-77-9

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-(3-methyl-2-pyridinyl)-
• CAS NO: 64959-77-9
• Molecular Formula: C14H10N2O2
• Molecular Weight: 238.246
• Mol File: 64959-77-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-(3-methyl-2-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-(3-methyl-2-pyridinyl)-(64959-77-9)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-(3-methyl-2-pyridinyl)-(64959-77-9)

Safety Data

• Hazardous Substances Data: 64959-77-9(Hazardous Substances Data)

Usage

Derivative of isoindole

It is a modified version of the parent compound isoindole, which is a bicyclic aromatic organic compound.

Bicyclic aromatic structure

The compound has two interconnected rings within its structure, which contribute to its aromatic properties.

Isoindole-1,3(2H)-dione ring

The central ring structure of the compound features a 1,3-dione group, which consists of two carbonyl groups (C=O) connected by a shared oxygen atom.

2-(3-methyl-2-pyridinyl) substituent

A side group attached to the second carbon of the isoindole ring, which includes a 3-methyl-2-pyridinyl group. This group consists of a pyridine ring (a six-membered nitrogen-containing ring) with a methyl group (CH3) attached to the second carbon.

Potential applications

The compound may have possible uses in various fields, such as pharmaceuticals, agrochemicals, and materials science, due to its unique chemical properties.

Need for further research and analysis

In order to fully understand the potential uses and implications of the compound, additional research and analysis are necessary.

Upstream product

• 1603-40-3 3-methylpyridin-2-ylamine 
• 85-44-9 phthalic anhydride 

Downstream Products

• 7521-41-7 2-Aminonicotinaldehyde 
• 381226-60-4 2-(3-bromomethyl-pyridin-2-yl)-isoindole-1,3-dione 
• 114858-36-5 2-<3-(dibromomethyl)-2-pyridinyl>-1H-isoindole-1,3(2H)-dione 
• 113402-98-5 2-(3-(triethoxysilyl)propyl)isoindoline-1,3-dione 

Relevant articles and documents

Synthesis, characterization, electronic absorption and antimicrobial studies of N-(silatranylpropyl)phthalimide derived from phthalic anhydride

The transimidization reaction between phthalic anhydride and (3-aminopropyl)triethoxysilane was carried out using 2-(3-methylpyridin-2-yl)isoindoline-1,3-dione 1 to synthesize N-(triethoxysilylpropyl)phthalimide 2 in good yield. New silatranes 3 and 4 containing phthalimide as exocyclic group were prepared by the transesterification reactions of N-(triethoxysilylpropyl)phthalimide 2 with triethanolamine and trisisopropanolamine respectively. All the compounds were characterized by elemental analysis, spectroscopic techniques and thermogravimetric analysis. The compounds 3 and 4 were also characterized by X-ray diffraction analysis. The electronic absorption spectra of compounds 3 and 4 were studied in six solvents with different polarities. N-(silatranylpropyl)phthalimides were evaluated for the preliminary antimicrobial activity using broth microdilution method.

Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or αvβ5 integrin.

New anti-inflammatory N-pyridinyl(alkyl)phthalimides acting as tumour necrosis factor-α production inhibitors

This paper describes the synthesis of N-pyridinyl(alkyl)phthalimides related to N-phenyl-4,5,6,7-tetrafluorophthalimides known to be inhibitors of tumour necrosis factor-α (TNFα) production. Pharmacomodulation at the phthalimidic nitrogen led to the selection of two pharmacophoric fragments (2,4-lutidinyl and β-picolyl), allowing significant inhibition of TNFα production (compounds 12 and 17). Variation of the substituents linked to the homocycle of their phthalimide scaffold indicated that high (TNFα production) inhibitory potency could be achieved, notably by 5-fluoro, 4- or 5-nitro, 5-amino and especially tetrafluoro substitution. The most active compound, N-(pyridin-3-ylmethyl)-4,5,6,7-tetrafluorophthalimide (32) (84% inhibition at 10 μM), also produced an anti-oedematous effect in the PMA-induced mouse-ear swelling test. Although less active than dexamethasone, it exerted a marked reduction in ear thickness after oral administration (63% vs. 85% for dexamethasone at 0.2 mM kg-1) and remained efficient after topical application (46% vs. 96% for the dexamethasone). It also induced potent inhibition in the rat carrageenan foot oedema test with an ID50 (0.14 μM kg-1) comparable with that of N-(2,6-diisopropylphenyl)phthalimide (4) (0.15 μM kg-1).