64965-48-6

Basic information

• Product Name: 3-IODO-QUINOLIN-4-OL
• Synonyms: 3-IODO-QUINOLIN-4-OL;4-Quinolinol, 3-iodo-;3-iodo-4-Quinolinol
• CAS NO: 64965-48-6
• Molecular Formula: C₉H₆INO
• Molecular Weight: 271.05451
• Mol File: 64965-48-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-IODO-QUINOLIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-QUINOLIN-4-OL(64965-48-6)
• EPA Substance Registry System: 3-IODO-QUINOLIN-4-OL(64965-48-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 64965-48-6(Hazardous Substances Data)

Usage

General Description

3-Iodo-quinolin-4-ol, also known as 4-hydroxy-3-iodoquinoline, is a chemical compound classified as a part of the quinolines. As suggested by its name, it is a derivative of quinoline with an iodine atom attached to the third carbon atom and a hydroxyl group attached to the fourth carbon atom. This chemical compound is recognized for its broad scope of pharmaceutical applications due to its antimalarial, antibacterial, antifungal, and anticancer properties. However, comprehensive information regarding its safety measures, environmental impact, physicochemical properties, and detailed applications are limited and requires further research for complete characterization.

InChI:InChI=1S/C9H6INO/c10-7-5-11-8-4-2-1-3-6(8)9(7)12/h1-5H,(H,11,12)

Upstream product

• 611-36-9 quinolin-4-ol 
• 855634-00-3 4-hydroxy-3-iodo-quinoline-2-carboxylic acid 
• 24782-43-2 ethyl 4-hydroxyquinoline-2-carboxylate 
• 855633-99-7 4-hydroxy-3-iodo-quinoline-2-carboxylic acid ethyl ester 

Downstream Products

• 1268468-60-5 3-(4-methoxy-phenyl)-4-(2-methyl-tetrahydro-furan-3-ylsulfanyl)-quinoline 
• 1449680-37-8 2-phenylfuro[3,2-c]quinoline 5-oxide 
• 1449680-40-3 2-phenylfuro[3,2-c]quinolin-4-amine 
• 1449680-34-5 2-phenylfuro[3,2-c]quinoline 

Relevant articles and documents

AZABICYCLIC(THIO)AMIDES AS FUNGICIDAL COMPOUNDS

The present invention relates to azabicyclic (thio)amide compounds and the uses thereof for controlling phytopathogenic microorganisms such as phytopathogenic fungi. It also relates to processes and intermediates for preparing these compounds

Exquisite selectivity for human toll-like receptor 8 in substituted furo[2,3-c]quinolines

Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds may be promising candidate adjuvants. We synthesized and evaluated hitherto unexplored furo[2,3-c]quinolines and regioisomeric furo[3,2-c]quinolines derived via a tandem, one-pot Sonogashira coupling and intramolecular 5-endo-dig cyclization strategy in a panel of primary screens. We observed a pure TLR8-agonistic activity profile in select furo[2,3-c] quinolines, with maximal potency conferred by a C2-butyl group (EC50 = 1.6 μM); shorter, longer, or substituted homologues as well as compounds bearing C1 substitutions were inactive, which was rationalized by docking studies using the recently described crystal structure of human TLR8. The best-in-class compound displayed prominent proinflammatory cytokine induction (including interleukin-12 and interleukin-18), but was bereft of interferon-α inducing properties, confirming its high selectivity for human TLR8.

SUBSTITUTED PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE TO TREAT OXIDATIVE STRESS

Substituted pyridine derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted pyridine derivative, and methods of use in treating inflammation are provided. The substituted pyridine derivatives may control of the act