650-93-1

Basic information

• Product Name: 2,2-difluoro-2-(3-nitrophenyl)acetic acid
• Synonyms: 2,2-difluoro-2-(3-nitrophenyl)acetic acid
• CAS NO: 650-93-1
• Molecular Weight: 217.129
• Mol File: 650-93-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,2-difluoro-2-(3-nitrophenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-difluoro-2-(3-nitrophenyl)acetic acid(650-93-1)
• EPA Substance Registry System: 2,2-difluoro-2-(3-nitrophenyl)acetic acid(650-93-1)

Safety Data

• Hazardous Substances Data: 650-93-1(Hazardous Substances Data)

Usage

General Description

2,2-difluoro-2-(3-nitrophenyl)acetic acid is a chemical compound with the molecular formula C8H5F2NO4. It is a derivative of acetic acid, with two fluorine atoms and a nitrophenyl group attached to the carbon atom. 2,2-difluoro-2-(3-nitrophenyl)acetic acid is typically used as a building block in organic synthesis, and it is known for its ability to act as a precursor in the production of various pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, it has potential applications in the field of medicinal chemistry and drug discovery due to its unique structural features and reactivity. Overall, 2,2-difluoro-2-(3-nitrophenyl)acetic acid plays a crucial role in the development of various chemical and pharmaceutical products.

Upstream product

• 99-09-2 3-nitro-aniline 
• 1260657-68-8 ethyl 2,2-difluoro-2-(3-nitrophenyl)acetate 
• 383-19-7 2,2-difluoro-2-phenylacetamide 
• 2002-72-4 α,α-difluorobenzeneacetonitrile 
• 40626-45-7 α,α-dichlorobenzylcyanide 
• 360-03-2 2,2-Difluoro-2-phenylacetic acid 

Downstream Products

• 402-03-9 (3-amino-phenyl)-difluoro-acetic acid 

Relevant articles and documents

Synthetic method of aromatic ring group or aromatic heterocyclic tetrazole

The synthetic method comprises the following steps: (1) reacting 1.0 eq of ArI or HArI with 1.2 eq of ethyl 2, 2-difluoroacetate in the presence of DMSO as a solvent and 4.0 eq of Cu under the protection of nitrogen at 30 DEG C and 50 DEG C, and purifying to obtain a first intermediate compound; (2) dissolving 1.0 eq of the first intermediate compound in a mixed solvent of THF and water, adding 2.0 eq of LiOH, reacting at room temperature for 2 hours, spin-drying the solvent, adding HCl until the pH value is equal to 3, and filtering to obtain a second intermediate compound; and (3) reacting 1.0 eq of the second intermediate compound with 2.0 eq of diphenyl azide phosphate in the presence of 2.5 eq of triethylamine by taking tert-butyl alcohol as a solvent to generate aromatic ring group or aromatic heterocyclic tetrazole. The invention provides a novel synthetic method of aromatic ring group or aromatic heterocyclic tetrazole, wherein a target compound can be more conveniently obtained, and reagents participating in the reaction are low in toxicity, mild in reaction condition, simple and safe in aftertreatment, good in product quality and suitable for large-scale production.

Easy Access to Difluoromethylene-Containing Arene Analogues through Palladium-Catalysed C–H Olefination

An efficient palladium-catalysed ortho-C–H olefination of α,α-difluorophenylacetic acid derivatives using 8-aminoquinoline as a bidentate directing group has been developed. A range of olefinated arenes can thus be synthesized in a concise way. This reaction provides an easy and straightforward route to a panel of difluoromethylated arene analogues in moderate to good yields, with a satisfactory tolerance of common functional groups. Transformation of the products into a variety of other difluoromethylene-containing compounds demonstrates the utility of this method.