65032-47-5

Basic information

• Product Name: Benzenesulfonamide, N-cyclobutyl-4-methyl-
• CAS NO: 65032-47-5
• Molecular Formula: C11H15NO2S
• Molecular Weight: 225.312
• Mol File: 65032-47-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-cyclobutyl-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-cyclobutyl-4-methyl-(65032-47-5)
• EPA Substance Registry System: Benzenesulfonamide, N-cyclobutyl-4-methyl-(65032-47-5)

Safety Data

• Hazardous Substances Data: 65032-47-5(Hazardous Substances Data)

Upstream product

• 2516-34-9 cyclobutylamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 941-55-9 4-toluenesulfonyl azide 
• 1065010-88-9 potassium cyclobutyltrifluoroboranuide 

Downstream Products

• 65032-53-3 N-(1-Methoxy-4-nitroso-butyl)-4-methyl-benzenesulfonamide 
• 65032-51-1 4-Methyl-N-[4-nitroso-but-(E)-ylidene]-benzenesulfonamide 
• 65032-52-2 N-Cyclobutylidene-4-methyl-benzenesulfonamide 
• 66121-74-2 C₁₁H₁₄BrNO₂S 
• 66169-67-3 C₁₁H₁₄ClNO₂S 
• 6139-84-0 4-chlorobutyraldehyde 
• 38694-47-2 4-bromobutyraldehyde 

Relevant articles and documents

Direct Synthesis of α-Amino Nitriles from Sulfonamides via Base-Mediated C-H Cyanation

Herein, we disclose a transition-metal-free reaction system that enables α-cyanation of sulfonamides through C-H bond cleavage for the preparation of α-amino nitriles, including difficult-to-access all-alkyl α-tertiary scaffolds. More than 50 substrate examples prove a wide functional group tolerance. Additionally, its synthetic practicality is highlighted by gram-scalability and the late-stage modification of natural compounds. Mechanistic experiments suggest that this process involves in situ formation of an imine intermediate via base-promoted elimination of HF.