65033-31-0

Basic information

• Product Name: Benzeneethanamine, a-methyl-4-(phenylmethoxy)-N-(phenylmethyl)-
• CAS NO: 65033-31-0
• Molecular Formula: C23H25NO
• Molecular Weight: 331.458
• Mol File: 65033-31-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzeneethanamine, a-methyl-4-(phenylmethoxy)-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanamine, a-methyl-4-(phenylmethoxy)-N-(phenylmethyl)-(65033-31-0)
• EPA Substance Registry System: Benzeneethanamine, a-methyl-4-(phenylmethoxy)-N-(phenylmethyl)-(65033-31-0)

Safety Data

• Hazardous Substances Data: 65033-31-0(Hazardous Substances Data)

Upstream product

• 5586-92-5 1-(4-benzyloxyphenyl)propan-2-one 
• 100-46-9 benzylamine 

Downstream Products

• 943962-11-6 (R)-(-)-1-(4-benzyloxyphenyl)-2-benzylaminopropane 
• 943962-12-7 (S)-(+)-1-(4-benzyloxyphenyl)-2-benzylaminopropane 
• 130156-24-0 (R,R)-(-)-Fenoterol 
• 130156-24-0 (S,S)-(+)-Fenoterol 
• 130156-24-0 (S,R)-5-(1-hydroxy-2-{[2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)benzene-1,3-diol 
• 391234-97-2 (R,S)-5-(1-hydroxy-2-{[2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)benzene-1,3-diol 
• 1026431-76-4 C₄₅H₄₅NO₄ 
• 1026647-78-8 C₄₅H₄₅NO₄ 
• 1026184-18-8 C₄₅H₄₅NO₄ 

Relevant articles and documents

Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the β2 adrenergic receptor

Stereoisomers of fenoterol and six fenoterol derivatives have been synthesized and their binding affinities for the β2 adrenergic receptor (Kiβ2-AR), the subtype selectivity relative to the β1-AR (Kiβ1-AR/K iβ2-AR) and their functional activities were determined. Of the 26 compounds synthesized in the study, submicromolar binding affinities were observed for (R,R)-fenoterol, the (R,R)-isomer of the p-methoxy, and (R,R)- and (R,S)-isomers of 1-naphthyl derivatives and all of these compounds were active at submicromolar concentrations in cardiomyocyte contractility tests. The Kiβ1-AR/K iβ2-AR ratios were >40 for (R,R)-fenoterol and the (R,R)-p-methoxy and (R,S)-1-naphthyl derivatives and 14 for the (R,R)-1-napthyl derivative. The binding data was analyzed using comparative molecular field analysis (CoMFA), and the resulting model indicated that the fenoterol derivatives interacted with two separate binding sites and one steric restricted site on the pseudo-receptor and that the chirality of the second stereogenic center affected Kiβ2 and subtype selectivity.

PREPARATION OF (R,R)-FENOTEROL AND (R,R)- OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE

This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.