6510-68-5

Basic information

• Product Name: 1,2-bis(4-methoxyphenyl)-2-(phenylamino)ethanone
• CAS NO: 6510-68-5
• Molecular Formula: C₂₂H₂₁NO₃
• Molecular Weight: 347.407
• Mol File: 6510-68-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 545.4°C at 760 mmHg
• Flash Point: 283.7°C
• Density: 1.18g/cm³
• Vapor Pressure: 5.93E-12mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: 1,2-bis(4-methoxyphenyl)-2-(phenylamino)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-bis(4-methoxyphenyl)-2-(phenylamino)ethanone(6510-68-5)
• EPA Substance Registry System: 1,2-bis(4-methoxyphenyl)-2-(phenylamino)ethanone(6510-68-5)

Safety Data

• Hazardous Substances Data: 6510-68-5(Hazardous Substances Data)

Usage

Appearance

Yellow, crystalline substance

Usage

Building block in organic synthesis

Applications

a. Production of pharmaceuticals
b. Production of agrochemicals
c. Reagent in chemical reactions
d. Starting material for synthesis of complex molecules
e. Component in perfumes and fragrances

Properties

a. Versatility in chemical reactions
b. Wide range of applications
c. Aromatic properties for use in fragrances

Upstream product

• 119-52-8 4,4'-dimethoxybenzoin 
• 62-53-3 aniline 
• 123-11-5 4-methoxy-benzaldehyde 
• 1613-96-3 N-(4-methoxybenzylidene)aniline 

Downstream Products

• 352196-57-7 1,2-bis(4-methoxyphenyl)-2-(methylphenylamino)ethanone 
• 352196-58-8 2-(ethylphenylamino)-1,2-bis(4-methoxyphenyl)ethanone 
• 5782-20-7 1-ethyl-2,3-bis(4-methoxyphenyl)-1H-indole 
• 5784-91-8 2,3-bis(4-methoxyphenyl)-1-methyl-1H-indole 
• 21096-63-9 ms--4,4'-dimethoxy-desoxybenzoin 
• 21096-62-8 MS-(N-Benzoyl-anilino)-4,4'-dimethoxy-desoxy-benzoin 

Relevant articles and documents

The Acceleration of the Rearrangement of α-Hydroxy Aldimines by Lewis or Bronsted Acids

An efficient method was developed for the synthesis of α-amino ketones from α-hydroxy imines. The reaction occurs through an α-iminol rearrangement involving the migration of a substituent of the carbinol carbon to the imine carbon. The optimal catalysts were found to be silica gel or montmorillonite K 10, which effected migration of a variety of aryl and alkyl substituents in high yields. The rearrangement can also be carried out on imines generated in situ from aldehydes and amines in essentially the same yields as those from the preformed imines.

Thiazolium-derived N-heterocyclic carbene-catalyzed cross-coupling of aldehydes with unactivated imines

Cross-coupling of aromatic aldehydes or benzoins with unactivated imines catalyzed by an N-heterocyclic carbene (NHC) affords α-amino ketones smoothly. The Royal Society of Chemistry.