651027-06-4

Basic information

• Product Name: Benzoic acid, 2,4-difluoro-3-(triethylsilyl)-
• CAS NO: 651027-06-4
• Molecular Formula: C13H18F2O2Si
• Molecular Weight: 272.367
• Mol File: 651027-06-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2,4-difluoro-3-(triethylsilyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2,4-difluoro-3-(triethylsilyl)-(651027-06-4)
• EPA Substance Registry System: Benzoic acid, 2,4-difluoro-3-(triethylsilyl)-(651027-06-4)

Safety Data

• Hazardous Substances Data: 651027-06-4(Hazardous Substances Data)

Upstream product

• 372-18-9 1,3-Difluorobenzene 
• 994-30-9 triethylsilyl chloride 
• 124-38-9 carbon dioxide 
• 651027-02-0 1-triethylsilyl-2,6-difluorobenzene 

Downstream Products

• 651026-98-1 3-bromo-2,4-difluorobenzoic acid 
• 1583-58-0 2,4-difluoro-benzoic acid 

Relevant articles and documents

Fluorine-flanked congested sites: Minimal, though perceptible buttressing effects on the proton mobility of arenes

(2,6-Difluorophenyl)trimethylsilane, -triethylsilane and -triisopropylsilane undergo sec-butyllithium-mediated metalation at the 3- and 4-position (ortho and meta relative to the halogen) in ratios of 99.6:0.4, 98:2 and 95:5, respectively. The steric pressure transmitted by the fluorine atoms can be increased if the trialkylsilyl group is locked up on the other side by a relatively voluminous substituent. Whereas (2,6-difluorophenyl)triethylsilane is attacked by lithium 2,2,6,6-tetramethylpiperidide under deprotonation of the 4- and 5-position in a ratio of 99.4:0.6, the proportion of "ortho"/ "meta" metalation changes to 84:16 when (2-bromo-6-fluorophenyl) triethylsilane acts as the substrate. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.