651053-61-1

Basic information

• Product Name: 1(4H)-Pyridinecarboxylic acid, 4-(1,1-dimethylethyl)-, phenyl ester
• CAS NO: 651053-61-1
• Molecular Formula: C16H19NO2
• Molecular Weight: 257.332
• Mol File: 651053-61-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1(4H)-Pyridinecarboxylic acid, 4-(1,1-dimethylethyl)-, phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1(4H)-Pyridinecarboxylic acid, 4-(1,1-dimethylethyl)-, phenyl ester(651053-61-1)
• EPA Substance Registry System: 1(4H)-Pyridinecarboxylic acid, 4-(1,1-dimethylethyl)-, phenyl ester(651053-61-1)

Safety Data

• Hazardous Substances Data: 651053-61-1(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 7565-59-5 tert-butylzinc bromide 
• 1885-14-9 phenyl chloroformate 

Downstream Products

• 1882-42-4 4-tert-butylpiperidine 
• 651053-82-6 phenyl 4-tert-butylpiperidine-1-carboxylate 

Relevant articles and documents

Efficient Solution-Phase Parallel Synthesis of 4-Substituted N-Protected Piperidines

Practical conditions for the synthesis of 4-substituted N-protected piperidines through CuCN·2LiBr-catalyzed organozinc additions to 1-acylpyridinium salts and subsequent hydrogen-transfer hydrogenation have been established. The reaction sequence is performed at room temperature and provides 4-substituted N-protected piperidines in excellent overall yields without the isolation of intermediate dihydropyridines, In those cases in which the organozinc addition results in mixtures of 2- and 4-substituted dihydropyridines, the 2-substituted isomers are efficiently scavenged with maleic anhydride and subsequently removed by a mild extractive workup with NaHCO3 (sat.). The N-acyl group can conveniently be exchanged from N-phenoxycarbonyl to N-tBoc, thus allowing orthogonal deprotection strategies. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.